Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4938960..4939696 Replicon chromosome
Accession NC_020211
Organism Serratia marcescens WW4

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7DEM5
Locus tag SMWW4_RS23130 Protein ID WP_015379310.1
Coordinates 4939217..4939696 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7DAD3
Locus tag SMWW4_RS23125 Protein ID WP_015379309.1
Coordinates 4938960..4939220 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMWW4_RS23105 4935030..4935710 + 681 WP_004930298.1 GMP/IMP nucleotidase -
SMWW4_RS23110 4935707..4936114 + 408 WP_015379306.1 ribosome-associated heat shock protein Hsp15 -
SMWW4_RS23115 4936140..4937018 + 879 WP_015379307.1 Hsp33 family molecular chaperone HslO -
SMWW4_RS23120 4937213..4938832 + 1620 WP_015379308.1 phosphoenolpyruvate carboxykinase (ATP) -
SMWW4_RS23125 4938960..4939220 + 261 WP_015379309.1 plasmid stability-like protein Antitoxin
SMWW4_RS23130 4939217..4939696 + 480 WP_015379310.1 type II toxin-antitoxin system VapC family toxin Toxin
SMWW4_RS23135 4939729..4941099 - 1371 WP_015379311.1 two-component system sensor histidine kinase EnvZ -
SMWW4_RS23140 4941096..4941815 - 720 WP_004709363.1 two-component system response regulator OmpR -
SMWW4_RS23145 4942073..4942378 - 306 WP_004930739.1 chaperone-modulator protein CbpM -
SMWW4_RS23150 4942384..4943346 - 963 WP_015379312.1 curved DNA-binding protein -
SMWW4_RS23155 4943576..4944049 + 474 WP_004930745.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17998.63 Da        Isoelectric Point: 5.9070

>T28854 WP_015379310.1 NC_020211:4939217-4939696 [Serratia marcescens WW4]
MIVLDTNVVSELLRPAPHYNVLRWLDEQDTYRFYLSAIVVAELYTGIACMPHGKKQLELQTNLGDMLQEEFSDRILPFDV
GCAMQHAELMGANRRRGIGVSMPDTQIAATCLHYGAALATRNTKDFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Download         Length: 480 bp

>T28854 NC_020211:4939217-4939696 [Serratia marcescens WW4]
ATGATTGTGCTGGATACCAACGTCGTTTCGGAATTGCTGCGGCCGGCGCCTCACTACAATGTATTGCGCTGGTTAGATGA
GCAGGATACGTATCGGTTCTATTTGAGCGCCATCGTGGTTGCGGAGTTGTATACGGGCATCGCCTGCATGCCTCACGGCA
AGAAACAGCTCGAACTGCAAACTAACCTCGGCGACATGCTGCAGGAAGAGTTTTCAGACAGAATCTTACCCTTTGACGTC
GGCTGTGCGATGCAGCATGCGGAATTAATGGGCGCCAATCGCCGCCGAGGCATTGGCGTCAGCATGCCGGATACCCAAAT
CGCCGCCACCTGCCTGCATTACGGCGCCGCCCTGGCCACCCGCAATACCAAAGACTTCCTCCACTGCGGCATCGAGTTAA
TCGATCCGTGGCAGGCGCCGACCGGCCGTCGGTTGCATGAAGATGCGGCGGAATACTACGTGATGAGCAGAAAGTCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9907.29 Da        Isoelectric Point: 5.1898

>AT28854 WP_015379309.1 NC_020211:4938960-4939220 [Serratia marcescens WW4]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTRMHQYFAEFGGVELEIPPRDEAPHRIVNF
DEDDEK

Download         Length: 261 bp

>AT28854 NC_020211:4938960-4939220 [Serratia marcescens WW4]
ATGGCGACTATCACCGTCAGAAATCTGGACGACGAAATCAAAGAACTGCTGCGTATTTCAGCGGCGAAAAACGGCCACTC
CATGGAAGAGGAAGCGCGCATGATCCTGAAGCAGGCGCTGGTGAAAAAGCCGCCGCGCTATGGGTTAGGAACACGCATGC
ATCAGTACTTCGCCGAATTCGGCGGCGTTGAGTTGGAGATCCCCCCACGTGATGAGGCCCCTCATCGTATCGTCAACTTT
GATGAAGATGATGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7DEM5

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7DAD3

References