Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 285542..286154 Replicon chromosome
Accession NZ_LR594048
Organism Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag FGL22_RS01560 Protein ID WP_000384858.1
Coordinates 285542..285877 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag FGL22_RS01565 Protein ID WP_000255538.1
Coordinates 285867..286154 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL22_RS01530 280562..280888 + 327 WP_000384270.1 replication initiator protein A -
FGL22_RS01535 280892..281521 + 630 WP_000591148.1 hypothetical protein -
FGL22_RS01540 281834..282709 + 876 WP_000770113.1 hypothetical protein -
FGL22_RS01545 282745..283179 + 435 WP_001220479.1 hypothetical protein -
FGL22_RS01550 283495..284715 + 1221 Protein_253 plasmid recombination protein -
FGL22_RS01555 284767..285237 + 471 WP_000130119.1 hypothetical protein -
FGL22_RS01560 285542..285877 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL22_RS01565 285867..286154 - 288 WP_000255538.1 hypothetical protein Antitoxin
FGL22_RS01570 286559..287170 - 612 WP_171842254.1 tyrosine-type recombinase/integrase -
FGL22_RS01575 287302..288165 - 864 WP_046177583.1 IS982 family transposase -
FGL22_RS01585 288961..290899 + 1939 Protein_259 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 287302..288165 863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T288538 WP_000384858.1 NZ_LR594048:c285877-285542 [Streptococcus dysgalactiae subsp. equisimilis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT288538 WP_000255538.1 NZ_LR594048:c286154-285867 [Streptococcus dysgalactiae subsp. equisimilis]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References