Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1413666..1414149 Replicon chromosome
Accession NZ_LR594043
Organism Streptococcus suis strain NCTC10237

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag FGL16_RS07440 Protein ID WP_009910443.1
Coordinates 1413666..1413926 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag FGL16_RS07445 Protein ID WP_012775256.1
Coordinates 1413928..1414149 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL16_RS07415 1409051..1410280 - 1230 WP_014736149.1 tetratricopeptide repeat protein -
FGL16_RS07420 1410270..1411436 - 1167 WP_002935690.1 AI-2E family transporter -
FGL16_RS07425 1411572..1412576 + 1005 WP_014736150.1 lactonase family protein -
FGL16_RS07430 1412640..1412825 + 186 WP_002935693.1 hypothetical protein -
FGL16_RS07435 1412858..1413499 - 642 WP_002935700.1 HAD family hydrolase -
FGL16_RS07440 1413666..1413926 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL16_RS07445 1413928..1414149 - 222 WP_012775256.1 hypothetical protein Antitoxin
FGL16_RS07450 1414373..1415680 - 1308 WP_002935704.1 phosphopyruvate hydratase -
FGL16_RS07455 1415830..1416282 + 453 WP_024405234.1 DUF1694 domain-containing protein -
FGL16_RS07465 1416509..1417637 - 1129 Protein_1356 glycerate kinase -
FGL16_RS07470 1417764..1418414 + 651 WP_014736153.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T288530 WP_009910443.1 NZ_LR594043:c1413926-1413666 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT288530 WP_012775256.1 NZ_LR594043:c1414149-1413928 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References