Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 955262..955757 Replicon chromosome
Accession NZ_LR594043
Organism Streptococcus suis strain NCTC10237

Toxin (Protein)


Gene name relE Uniprot ID A0A4V0E2N5
Locus tag FGL16_RS05040 Protein ID WP_014735845.1
Coordinates 955262..955528 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V0E2R6
Locus tag FGL16_RS05045 Protein ID WP_014735844.1
Coordinates 955518..955757 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL16_RS05020 950901..951971 + 1071 WP_014735849.1 tyrosine recombinase XerS -
FGL16_RS05025 952034..953542 - 1509 WP_014735848.1 phosphoglucomutase -
FGL16_RS05030 953617..954558 - 942 WP_014735847.1 sensor histidine kinase -
FGL16_RS05035 954555..955220 - 666 WP_024405277.1 response regulator transcription factor -
FGL16_RS05040 955262..955528 - 267 WP_014735845.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL16_RS05045 955518..955757 - 240 WP_014735844.1 hypothetical protein Antitoxin
FGL16_RS05050 956083..957285 + 1203 WP_138083581.1 IS110 family transposase -
FGL16_RS05060 957667..959613 - 1947 WP_014735842.1 FtsX-like permease family protein -
FGL16_RS05065 959614..960366 - 753 WP_014735841.1 ABC transporter ATP-binding protein -
FGL16_RS05070 960375..960749 - 375 WP_029694721.1 NisI/SpaI family lantibiotic immunity lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 956047..957285 1238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10318.02 Da        Isoelectric Point: 10.3331

>T288529 WP_014735845.1 NZ_LR594043:c955528-955262 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDDCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8909.12 Da        Isoelectric Point: 3.7832

>AT288529 WP_014735844.1 NZ_LR594043:c955757-955518 [Streptococcus suis]
MTAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0E2N5

Antitoxin

Source ID Structure
AlphaFold DB A0A4V0E2R6

References