Detailed information of TA system TA288528

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1251972..1253233
• Replicon: chromosome
• Accession: NZ_LR594041
• Organism: Streptococcus gordonii strain NCTC9124

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: FGL12_RS06010
• Protein ID: WP_061600507.1
• Coordinates: 1251972..1252757 (-)
• Length: 262 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: FGL12_RS06015
• Protein ID: WP_061600509.1
• Coordinates: 1252757..1253233 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL12_RS05995	1247402..1247992	-	591	WP_061600501.1	hypothetical protein	-
FGL12_RS06000	1248036..1249961	-	1926	WP_061600503.1	ATP-dependent helicase	-
FGL12_RS06005	1249943..1251982	-	2040	WP_061600505.1	ATP-dependent endonuclease	-
FGL12_RS06010	1251972..1252757	-	786	WP_061600507.1	zeta toxin family protein	Toxin
FGL12_RS06015	1252757..1253233	-	477	WP_061600509.1	helix-turn-helix domain-containing protein	Antitoxin
FGL12_RS06020	1253358..1254968	-	1611	WP_061600511.1	ABC transporter ATP-binding protein/permease	-
FGL12_RS06025	1255365..1256231	-	867	WP_061600512.1	helix-turn-helix transcriptional regulator	-
FGL12_RS06030	1256381..1256452	-	72	Protein_1166	peptidylprolyl isomerase	-
FGL12_RS06035	1256715..1257878	-	1164	WP_061600515.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1241722..1271115	29393

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 262 a.a.
• Molecular weight: 29965.08 Da
• Isoelectric Point: 6.2547

>T288528 WP_061600507.1 NZ_LR594041:c1252757-1251972 [Streptococcus gordonii]
MKLEEFSQDDFERASRRLVRSLTRGKTNSSQPKAILLGGQSGAGKTTIHRVKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGRMVEYLVDELSKLGYHLLIEGTLRTTEVPRKTAQLLITKGYQVSLALIATKPELSYLSTLIRYEE
LYTIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCVYDSEVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLRELMEMKKGIIDGN

Nucleotide

• Length: 786 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18038.48 Da
• Isoelectric Point: 4.3745

>AT288528 WP_061600509.1 NZ_LR594041:c1253233-1252757 [Streptococcus gordonii]
MIGENIKALRKTHDLTQPEFAKIVGISRNSLSRYENGISSVSTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLLNTKIYLVGTFDEVERYNGYLDGIERMLEQASHLVVA

Nucleotide

• Length: 477 bp