Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1199432..1200106 Replicon chromosome
Accession NZ_LR594040
Organism Streptococcus australis strain NCTC5338

Toxin (Protein)


Gene name hicA Uniprot ID J4TEA9
Locus tag FGK98_RS05995 Protein ID WP_001132280.1
Coordinates 1199432..1199611 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGK98_RS06000 Protein ID WP_138100464.1
Coordinates 1199654..1200106 (+) Length 151 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK98_RS05960 1194966..1195298 + 333 WP_138100458.1 DNA-binding protein -
FGK98_RS05965 1195291..1195569 + 279 WP_138100459.1 XRE family transcriptional regulator -
FGK98_RS05970 1195580..1196359 + 780 WP_138100460.1 phage replisome organizer N-terminal domain-containing protein -
FGK98_RS05975 1196375..1197199 + 825 WP_138100461.1 ATP-binding protein -
FGK98_RS05980 1197224..1197682 + 459 WP_138100462.1 hypothetical protein -
FGK98_RS05985 1197780..1198289 + 510 WP_138101048.1 hypothetical protein -
FGK98_RS05990 1198790..1199209 + 420 WP_138100463.1 DUF1492 domain-containing protein -
FGK98_RS05995 1199432..1199611 + 180 WP_001132280.1 type II toxin-antitoxin system HicA family toxin Toxin
FGK98_RS06000 1199654..1200106 + 453 WP_138100464.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGK98_RS06005 1200223..1200432 + 210 WP_138100465.1 hypothetical protein -
FGK98_RS06010 1200976..1201902 - 927 WP_138100466.1 aldo/keto reductase -
FGK98_RS06020 1202260..1204284 - 2025 WP_138100467.1 glucosaminidase domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1190709..1200432 9723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 60 a.a.        Molecular weight: 6642.83 Da        Isoelectric Point: 10.7304

>T288527 WP_001132280.1 NZ_LR594040:1199432-1199611 [Streptococcus australis]
MPMTQKEMVKLLTAHGWIKTKGGKGSHVKMEKEGERPITVPHGELNKYTERGIRKQAGL

Download         Length: 180 bp


Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16662.60 Da        Isoelectric Point: 3.8817

>AT288527 WP_138100464.1 NZ_LR594040:1199654-1200106 [Streptococcus australis]
MLVTYPALFYYDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGINLADYIENGREIPTPTPINALSLANNNPF
RDDEDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRDLGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4V0BVY2


Antitoxin

Source ID Structure

References