Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5681572..5682182 Replicon chromosome
Accession NZ_LR594038
Organism Klebsiella grimontii strain NCTC9146 substr. serovar casular

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E1GAR7
Locus tag FGL39_RS27015 Protein ID WP_049086919.1
Coordinates 5681572..5681946 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FGL39_RS27020 Protein ID WP_077253475.1
Coordinates 5681943..5682182 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL39_RS27000 5678727..5679629 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
FGL39_RS27005 5679626..5680261 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
FGL39_RS27010 5680605..5681534 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
FGL39_RS27015 5681572..5681946 - 375 WP_049086919.1 type II toxin-antitoxin system VapC family toxin Toxin
FGL39_RS27020 5681943..5682182 - 240 WP_077253475.1 ribbon-helix-helix domain-containing protein Antitoxin
FGL39_RS27025 5682388..5683305 + 918 WP_024360706.1 alpha/beta hydrolase -
FGL39_RS27030 5683323..5684264 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
FGL39_RS27035 5684309..5684746 - 438 WP_004132870.1 D-tyrosyl-tRNA(Tyr) deacylase -
FGL39_RS27040 5684743..5685603 - 861 WP_004127107.1 virulence factor BrkB family protein -
FGL39_RS27045 5685597..5686196 - 600 WP_004132872.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14111.45 Da        Isoelectric Point: 8.4571

>T288525 WP_049086919.1 NZ_LR594038:c5681946-5681572 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT288525 WP_077253475.1 NZ_LR594038:c5682182-5681943 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References