Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5097591..5098271 Replicon chromosome
Accession NZ_LR594038
Organism Klebsiella grimontii strain NCTC9146 substr. serovar casular

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FGL39_RS24245 Protein ID WP_138110258.1
Coordinates 5097591..5097911 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FGL39_RS24250 Protein ID WP_138110260.1
Coordinates 5097948..5098271 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL39_RS24210 5093283..5093855 - 573 WP_138110252.1 hypothetical protein -
FGL39_RS24215 5093883..5094359 - 477 WP_049090447.1 DUF1643 domain-containing protein -
FGL39_RS24220 5094387..5094854 - 468 WP_138110254.1 hypothetical protein -
FGL39_RS27585 5095054..5095206 - 153 WP_171016413.1 hypothetical protein -
FGL39_RS24230 5096020..5096295 - 276 WP_049617298.1 type II toxin-antitoxin system RelE/ParE family toxin -
FGL39_RS24235 5096299..5096547 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
FGL39_RS24240 5096644..5097477 - 834 WP_138110256.1 DUF4942 domain-containing protein -
FGL39_RS24245 5097591..5097911 - 321 WP_138110258.1 TA system toxin CbtA family protein Toxin
FGL39_RS24250 5097948..5098271 - 324 WP_138110260.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FGL39_RS24255 5098284..5098754 - 471 WP_049617294.1 DNA repair protein RadC -
FGL39_RS24260 5098820..5099641 - 822 WP_138110262.1 DUF945 domain-containing protein -
FGL39_RS24265 5099737..5100204 - 468 WP_171016414.1 hypothetical protein -
FGL39_RS24270 5100249..5100665 - 417 WP_096924353.1 hypothetical protein -
FGL39_RS24275 5100773..5101462 - 690 WP_138110264.1 WYL domain-containing protein -
FGL39_RS24280 5101674..5102549 - 876 WP_138110266.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(8-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11983.63 Da        Isoelectric Point: 5.9538

>T288524 WP_138110258.1 NZ_LR594038:c5097911-5097591 [Klebsiella grimontii]
MHITTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEGHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12169.73 Da        Isoelectric Point: 4.3707

>AT288524 WP_138110260.1 NZ_LR594038:c5098271-5097948 [Klebsiella grimontii]
MSITPPYEWGLQSDITPRFGARLVQEGDRLYYLADRADLTGSFSPEQLQKLDQAFPLFVEQLEDMLRAGELNPHQQRQVN
IQLASLTCIADTRGSFGYVYISIYPTP

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References