Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4363532..4364151 Replicon chromosome
Accession NZ_LR594038
Organism Klebsiella grimontii strain NCTC9146 substr. serovar casular

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag FGL39_RS20770 Protein ID WP_004099646.1
Coordinates 4363933..4364151 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag FGL39_RS20765 Protein ID WP_004129911.1
Coordinates 4363532..4363906 (+) Length 125 a.a.

Genomic Context


FGL39_RS20755FGL39_RS20760FGL39_RS20765FGL39_RS20770FGL39_RS20775FGL39_RS20780FGL39_RS20790FGL39_RS20785FGL39_RS20795FGL39_RS20800
Location: 4358701..4359894 (1194 bp)
Type: Others
Protein ID: WP_138110236.1
Location: 4359917..4363063 (3147 bp)
Type: Others
Protein ID: WP_004848339.1
Location: 4363532..4363906 (375 bp)
Type: Antitoxin
Protein ID: WP_004129911.1
Location: 4363933..4364151 (219 bp)
Type: Toxin
Protein ID: WP_004099646.1
Location: 4364313..4364879 (567 bp)
Type: Others
Protein ID: WP_004136050.1
Location: 4365006..4365476 (471 bp)
Type: Others
Protein ID: WP_004136048.1
Location: 4367006..4367704 (699 bp)
Type: Others
Protein ID: WP_004136044.1
Location: 4365451..4366905 (1455 bp)
Type: Others
Protein ID: WP_049085239.1
Location: 4367701..4367841 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 4367841..4368104 (264 bp)
Type: Others
Protein ID: WP_004129897.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FGL39_RS207554358701..4359894+1194WP_138110236.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
FGL39_RS207604359917..4363063+3147WP_004848339.1multidrug efflux RND transporter permease subunit-
FGL39_RS207654363532..4363906+375WP_004129911.1Hha toxicity modulator TomBAntitoxin
FGL39_RS207704363933..4364151+219WP_004099646.1hemolysin expression modulator HhaToxin
FGL39_RS207754364313..4364879+567WP_004136050.1maltose O-acetyltransferase-
FGL39_RS207804365006..4365476+471WP_004136048.1YlaC family protein-
FGL39_RS207854365451..4366905-1455WP_049085239.1PLP-dependent aminotransferase family protein-
FGL39_RS207904367006..4367704+699WP_004136044.1GNAT family N-acetyltransferase-
FGL39_RS207954367701..4367841-141WP_003859006.1type B 50S ribosomal protein L36-
FGL39_RS208004367841..4368104-264WP_004129897.1type B 50S ribosomal protein L31-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T288521 WP_004099646.1 NZ_LR594038:4363933-4364151 [Klebsiella grimontii]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp


Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT288521 WP_004129911.1 NZ_LR594038:4363532-4363906 [Klebsiella grimontii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3H713


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3HD25

References