Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 832299..832956 Replicon chromosome
Accession NZ_LR594038
Organism Klebsiella grimontii strain NCTC9146 substr. serovar casular

Toxin (Protein)


Gene name cptA Uniprot ID A0A285B9I7
Locus tag FGL39_RS04060 Protein ID WP_004134421.1
Coordinates 832546..832956 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag FGL39_RS04055 Protein ID WP_004105561.1
Coordinates 832299..832565 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL39_RS04030 827478..828911 - 1434 WP_004133593.1 6-phospho-beta-glucosidase -
FGL39_RS04035 829033..829761 - 729 WP_024358621.1 MurR/RpiR family transcriptional regulator -
FGL39_RS04040 829812..830123 + 312 WP_004133599.1 N(4)-acetylcytidine aminohydrolase -
FGL39_RS04045 830286..830945 + 660 WP_004124978.1 hemolysin III family protein -
FGL39_RS04050 831072..832055 - 984 WP_049087337.1 tRNA-modifying protein YgfZ -
FGL39_RS04055 832299..832565 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
FGL39_RS04060 832546..832956 + 411 WP_004134421.1 protein YgfX Toxin
FGL39_RS04065 832965..833486 - 522 WP_004134423.1 flavodoxin FldB -
FGL39_RS04070 833608..834504 + 897 WP_004124942.1 site-specific tyrosine recombinase XerD -
FGL39_RS04075 834527..835240 + 714 WP_004134425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FGL39_RS04080 835246..836979 + 1734 WP_004134426.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.86 Da        Isoelectric Point: 10.9455

>T288514 WP_004134421.1 NZ_LR594038:832546-832956 [Klebsiella grimontii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT288514 WP_004105561.1 NZ_LR594038:832299-832565 [Klebsiella grimontii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285B9I7

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References