Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1491931..1492482 Replicon chromosome
Accession NZ_LR594037
Organism Streptococcus anginosus strain NCTC11064

Toxin (Protein)


Gene name relE Uniprot ID D0RWL8
Locus tag FGK97_RS07460 Protein ID WP_008809670.1
Coordinates 1492204..1492482 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5N1G2T1
Locus tag FGK97_RS07455 Protein ID WP_059221290.1
Coordinates 1491931..1492203 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK97_RS07435 1487306..1488061 - 756 WP_062200670.1 NTPase -
FGK97_RS07440 1488763..1489946 + 1184 Protein_1411 transposase -
FGK97_RS07445 1490033..1490884 - 852 WP_171004452.1 ImmA/IrrE family metallo-endopeptidase -
FGK97_RS07450 1490891..1491253 - 363 WP_002270986.1 helix-turn-helix domain-containing protein -
FGK97_RS07455 1491931..1492203 + 273 WP_059221290.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FGK97_RS07460 1492204..1492482 + 279 WP_008809670.1 type II toxin-antitoxin system YafQ family toxin Toxin
FGK97_RS07465 1492611..1492847 + 237 WP_138099486.1 hypothetical protein -
FGK97_RS07475 1493186..1493500 + 315 WP_138099488.1 hypothetical protein -
FGK97_RS07480 1493523..1493933 + 411 WP_138099489.1 DUF961 family protein -
FGK97_RS07485 1493940..1495598 + 1659 WP_138099490.1 cell division protein FtsK -
FGK97_RS07490 1496085..1496453 - 369 WP_003042548.1 EXLDI protein -
FGK97_RS07495 1496480..1497097 - 618 WP_138099491.1 DNA alkylation repair protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1446408..1619791 173383
- flank IS/Tn - - 1489566..1489946 380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10862.69 Da        Isoelectric Point: 8.0383

>T288513 WP_008809670.1 NZ_LR594037:1492204-1492482 [Streptococcus anginosus]
MYQVKFTSAFKKSYKRIKKRGLDIALLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEDDILTLTL
ADTGSHADLFKM

Download         Length: 279 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9875.32 Da        Isoelectric Point: 4.7247

>AT288513 WP_059221290.1 NZ_LR594037:1491931-1492203 [Streptococcus anginosus]
MATVPTQIRIDETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKRISRDEAVASYDN
LADLKKALEA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0RWL8

Antitoxin

Source ID Structure
AlphaFold DB A0A5N1G2T1

References