Detailed information of TA system TA028851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4605435..4606030
• Replicon: chromosome
• Accession: NC_020211
• Organism: Serratia marcescens WW4

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: SMWW4_RS25155
• Protein ID: WP_071605322.1
• Coordinates: 4605776..4606030 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SMWW4_RS21450
• Protein ID: WP_041922374.1
• Coordinates: 4605435..4605776 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMWW4_RS21435	4601626..4602441	-	816	WP_015379122.1	GPO family capsid scaffolding protein	-
SMWW4_RS21440	4602584..4604356	+	1773	WP_041922283.1	terminase ATPase subunit family protein	-
SMWW4_RS21445	4604356..4605390	+	1035	WP_015379124.1	phage portal protein	-
SMWW4_RS21450	4605435..4605776	-	342	WP_041922374.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SMWW4_RS25155	4605776..4606030	-	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
SMWW4_RS25160	4606507..4607274	-	768	WP_015379126.1	RloB family protein	-
SMWW4_RS21460	4607213..4608490	-	1278	WP_015379127.1	ATP-binding protein	-
SMWW4_RS21465	4608898..4609122	-	225	WP_015379128.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4578503..4616918	38415

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T28851 WP_071605322.1 NC_020211:c4606030-4605776 [Serratia marcescens WW4]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T28851 NC_020211:c4606030-4605776 [Serratia marcescens WW4]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12384.93 Da
• Isoelectric Point: 4.5789

>AT28851 WP_041922374.1 NC_020211:c4605776-4605435 [Serratia marcescens WW4]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAALATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT28851 NC_020211:c4605776-4605435 [Serratia marcescens WW4]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGAGAGTT
TGTCGGGCTGAATGGCGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAATGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCACTGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1