Detailed information of TA system TA288509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1077719..1078977
• Replicon: chromosome
• Accession: NZ_LR594036
• Organism: Streptococcus porcinus strain NCTC10710

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: FGK96_RS05100
• Protein ID: WP_138081968.1
• Coordinates: 1077719..1078501 (-)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: FGK96_RS05105
• Protein ID: WP_117508719.1
• Coordinates: 1078501..1078977 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGK96_RS05070	1072879..1074741	-	1863	WP_138081960.1	relaxase/mobilization nuclease domain-containing protein	-
FGK96_RS05075	1074728..1075093	-	366	WP_138081962.1	MobC family plasmid mobilization relaxosome protein	-
FGK96_RS05080	1075103..1075462	-	360	WP_138081964.1	hypothetical protein	-
FGK96_RS05090	1075791..1076933	-	1143	WP_013851910.1	AAA family ATPase	-
FGK96_RS05095	1076934..1077722	-	789	WP_013851911.1	hypothetical protein	-
FGK96_RS05100	1077719..1078501	-	783	WP_138081968.1	zeta toxin family protein	Toxin
FGK96_RS05105	1078501..1078977	-	477	WP_117508719.1	helix-turn-helix domain-containing protein	Antitoxin
FGK96_RS05110	1079047..1079337	-	291	WP_172601598.1	hypothetical protein	-
FGK96_RS05115	1079387..1079776	-	390	WP_138081972.1	chemotaxis protein	-
FGK96_RS05120	1079773..1080000	-	228	WP_138081974.1	hypothetical protein	-
FGK96_RS05125	1080054..1081129	-	1076	Protein_963	toprim domain-containing protein	-
FGK96_RS05130	1081168..1081806	-	639	WP_138081976.1	peptidylprolyl isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1058583..1100241	41658

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (30-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 29566.60 Da
• Isoelectric Point: 5.9904

>T288509 WP_138081968.1 NZ_LR594036:c1078501-1077719 [Streptococcus porcinus]
MRLEEFSEAEFQKALQRTIRALTRGKTILDKPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLKSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELESEKLFEQIQIYQRDRACIYDSETDKDSAAEVLQDCLFGEWSKVEEEML
KVGEEKLANLIDKNMIGSKK

Nucleotide

• Length: 783 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18287.70 Da
• Isoelectric Point: 4.3971

>AT288509 WP_117508719.1 NZ_LR594036:c1078977-1078501 [Streptococcus porcinus]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDMVNHRVVA

Nucleotide

• Length: 477 bp