Detailed information of TA system TA288508

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 882187..883615
• Replicon: chromosome
• Accession: NZ_LR594036
• Organism: Streptococcus porcinus strain NCTC10710

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: FGK96_RS04280
• Protein ID: WP_138081715.1
• Coordinates: 882773..883615 (+)
• Length: 281 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: FGK96_RS04275
• Protein ID: WP_138081713.1
• Coordinates: 882187..882780 (+)
• Length: 198 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGK96_RS04260	877905..880193	+	2289	WP_138081711.1	CHAP domain-containing protein	-
FGK96_RS04265	880206..880493	+	288	WP_026624440.1	conjugal transfer protein	-
FGK96_RS04270	880498..882093	+	1596	WP_138083497.1	DUF4366 domain-containing protein	-
FGK96_RS04275	882187..882780	+	594	WP_138081713.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
FGK96_RS04280	882773..883615	+	843	WP_138081715.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FGK96_RS04285	883787..885499	+	1713	WP_138081717.1	DNA topoisomerase 3	-
FGK96_RS04290	885503..886054	+	552	WP_138081719.1	NAD(P)-dependent oxidoreductase	-
FGK96_RS04295	886095..886841	+	747	WP_138081721.1	conjugal transfer protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-268)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-51)

Sequences

Toxin

Protein

• Length: 281 a.a.
• Molecular weight: 32580.82 Da
• Isoelectric Point: 6.5117

>T288508 WP_138081715.1 NZ_LR594036:882773-883615 [Streptococcus porcinus]
MNKAKLTALCHKVSKEVGLSFNAVMLYYFLESILKKLAGSKYSERFIFKGGFLLSSVVGIDSRSTVDIDFLLRNMQLSEE
NIVQMLKESLKSEESDDIIYEVQSILPIKEEDQYGGFRVNILCKMENIRQIVPLDIATGDVITPHPIDYKYVSSFGEEEI
IIKAYPIETMLAEKIQTIYARGFLNSRSKDYYDLYIIYKLKDKDVNVEILREACRKTFSYRKTEFDIGKIIDLLEKLKIN
EAFLKRWQAYSRKNLYAKDITFEEVLDNGIKMVEKIKNEN

Nucleotide

• Length: 843 bp

Antitoxin

Protein

• Length: 198 a.a.
• Molecular weight: 23371.84 Da
• Isoelectric Point: 8.6522

>AT288508 WP_138081713.1 NZ_LR594036:882187-882780 [Streptococcus porcinus]
MNYENKIEKYLKQSGGIITTAYCKENNIPTIYLSRLLKDGRLLKVRKGIYITKDGDYDEYYFFQHQYKKAIFSYETALYL
LGQTDKIPWSIDVTVYNGYKFNEKPNGFNVHYVKKSIYDLGVTQKPTMFGNKVKVYSYERTLCDFIAHKEEMDIEVYVKL
IQSYSSYKERDIHSLYDIAMKMGIENKVREVMEVAYE

Nucleotide

• Length: 594 bp