Detailed information of TA system TA288507

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1317701..1319133
• Replicon: chromosome
• Accession: NZ_LR594035
• Organism: Streptococcus pseudoporcinus strain NCTC5385

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: FGL04_RS06875
• Protein ID: WP_138068668.1
• Coordinates: 1318288..1319133 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: FGL04_RS06870
• Protein ID: WP_138068667.1
• Coordinates: 1317701..1318291 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL04_RS06835	1312804..1313361	-	558	WP_138069164.1	replication initiation factor domain-containing protein	-
FGL04_RS06840	1313922..1314260	-	339	WP_138068665.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FGL04_RS06845	1314250..1314537	-	288	WP_138068666.1	XRE family transcriptional regulator	-
FGL04_RS06855	1316033..1316407	+	375	Protein_1326	DDE-type integrase/transposase/recombinase	-
FGL04_RS06860	1316443..1317423	-	981	Protein_1327	glucan-binding protein	-
FGL04_RS06870	1317701..1318291	+	591	WP_138068667.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
FGL04_RS06875	1318288..1319133	+	846	WP_138068668.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FGL04_RS06880	1319196..1321847	-	2652	WP_138069165.1	CHAP domain-containing protein	-
FGL04_RS06890	1321955..1323087	+	1133	Protein_1331	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1272672..1333433	60761
	-	inside	IScluster/Tn	-	-	1306011..1316407	10396

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32503.32 Da
• Isoelectric Point: 6.4966

>T288507 WP_138068668.1 NZ_LR594035:1318288-1319133 [Streptococcus pseudoporcinus]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHRITLSED
TVKQQLKEILADSKEGISFTIQSITAIKESDDYGGYRATILCQLENIKQIIHLDIATGDIVTPQPITYDYKAIFNEDTFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLIAVLISINSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23058.56 Da
• Isoelectric Point: 7.7987

>AT288507 WP_138068667.1 NZ_LR594035:1317701-1318291 [Streptococcus pseudoporcinus]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp