Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 981456..982068 Replicon chromosome
Accession NZ_LR590625
Organism Streptococcus canis strain B700072

Toxin (Protein)


Gene name parE Uniprot ID A0A4V0C1F2
Locus tag FGK95_RS05045 Protein ID WP_003048651.1
Coordinates 981733..982068 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Q8EDD0
Locus tag FGK95_RS05040 Protein ID WP_017648215.1
Coordinates 981456..981743 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK95_RS05020 977009..978214 + 1206 WP_003048662.1 30S ribosomal protein S1 -
FGK95_RS05025 978336..979571 + 1236 WP_138114176.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
FGK95_RS05030 979683..980651 - 969 WP_093999033.1 polysaccharide deacetylase family protein -
FGK95_RS05035 980837..981279 + 443 Protein_913 hypothetical protein -
FGK95_RS05040 981456..981743 + 288 WP_017648215.1 hypothetical protein Antitoxin
FGK95_RS05045 981733..982068 + 336 WP_003048651.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGK95_RS05050 982691..983546 + 856 Protein_916 homoserine kinase -
FGK95_RS05055 983637..984905 + 1269 WP_093999035.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -
FGK95_RS05060 984937..985503 + 567 WP_093999036.1 GTP cyclohydrolase I FolE -
FGK95_RS05065 985512..986312 + 801 WP_093999037.1 dihydropteroate synthase -
FGK95_RS05070 986319..986678 + 360 WP_093999038.1 dihydroneopterin aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13215.04 Da        Isoelectric Point: 6.2385

>T288504 WP_003048651.1 NZ_LR590625:981733-982068 [Streptococcus canis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLKVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPARSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10949.53 Da        Isoelectric Point: 4.7271

>AT288504 WP_017648215.1 NZ_LR590625:981456-981743 [Streptococcus canis]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0C1F2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8EDD0

References