Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 126225..126902 Replicon chromosome
Accession NZ_LR590625
Organism Streptococcus canis strain B700072

Toxin (Protein)


Gene name hicA Uniprot ID V6Z2K9
Locus tag FGK95_RS00800 Protein ID WP_015647112.1
Coordinates 126225..126407 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGK95_RS00805 Protein ID WP_093998740.1
Coordinates 126447..126902 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK95_RS00765 122249..123076 - 828 WP_093999408.1 EbhA -
FGK95_RS00770 123502..124161 - 660 WP_093999409.1 helix-turn-helix transcriptional regulator -
FGK95_RS00775 124324..124523 + 200 Protein_103 helix-turn-helix transcriptional regulator -
FGK95_RS00780 124540..125175 + 636 WP_138114008.1 Bro-N domain-containing protein -
FGK95_RS00785 125189..125434 + 246 WP_164403324.1 phage antirepressor protein -
FGK95_RS00790 125689..126021 + 333 WP_050319961.1 hypothetical protein -
FGK95_RS00800 126225..126407 + 183 WP_015647112.1 type II toxin-antitoxin system HicA family toxin Toxin
FGK95_RS00805 126447..126902 + 456 WP_093998740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGK95_RS00810 127268..128527 - 1260 WP_138114011.1 tyrosine--tRNA ligase -
FGK95_RS00815 128634..130934 + 2301 WP_164403322.1 penicillin-binding protein PBP1B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(20-74)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6630.84 Da        Isoelectric Point: 10.8207

>T288502 WP_015647112.1 NZ_LR590625:126225-126407 [Streptococcus canis]
MPMTQKEMVKLLTANGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 17065.12 Da        Isoelectric Point: 4.0258

>AT288502 WP_093998740.1 NZ_LR590625:126447-126902 [Streptococcus canis]
MLVTYPALFYYDDTQGETVAPYFVTFPDFEYSATQGEDMADAMAMASEWLGINLADYIENGRDIPKPSDINSLSLVDNNP
FREDKDFRLTYDPNKSFISLVMVDVSEYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 456 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6Z2K9

Antitoxin

Source ID Structure

References