Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1582494..1583106 Replicon chromosome
Accession NZ_LR590483
Organism Streptococcus pyogenes strain NCTC8318

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag FGK91_RS08135 Protein ID WP_011018227.1
Coordinates 1582771..1583106 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag FGK91_RS08130 Protein ID WP_002988079.1
Coordinates 1582494..1582781 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK91_RS08100 1577672..1578655 - 984 WP_011285168.1 tagatose-bisphosphate aldolase -
FGK91_RS08105 1578659..1579588 - 930 WP_146710371.1 tagatose-6-phosphate kinase -
FGK91_RS08110 1579636..1580151 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
FGK91_RS08115 1580186..1580614 - 429 WP_146710372.1 galactose-6-phosphate isomerase subunit LacA -
FGK91_RS08120 1581060..1581833 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
FGK91_RS08130 1582494..1582781 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
FGK91_RS08135 1582771..1583106 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGK91_RS09355 1583258..1583728 + 471 Protein_1500 integrase -
FGK91_RS09360 1584061..1584210 + 150 WP_011285175.1 integrase -
FGK91_RS08150 1584330..1584722 - 393 WP_002982716.1 30S ribosomal protein S9 -
FGK91_RS08155 1584743..1585189 - 447 WP_002982710.1 50S ribosomal protein L13 -
FGK91_RS08160 1585407..1585613 - 207 WP_023078893.1 helix-turn-helix transcriptional regulator -
FGK91_RS08165 1585610..1586308 - 699 WP_023078900.1 hypothetical protein -
FGK91_RS08170 1586444..1587304 - 861 WP_011529009.1 DegV family protein -
FGK91_RS08175 1587401..1587919 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T288501 WP_011018227.1 NZ_LR590483:1582771-1583106 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT288501 WP_002988079.1 NZ_LR590483:1582494-1582781 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References