Detailed information of TA system TA288500

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 5590908..5591494
• Replicon: chromosome
• Accession: NZ_LR590482
• Organism: Pseudomonas synxantha strain NCTC10696

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FGL41_RS25915
• Protein ID: WP_014717392.1
• Coordinates: 5590908..5591216 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FGL41_RS25920
• Protein ID: WP_014717391.1
• Coordinates: 5591213..5591494 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL41_RS25885	5586744..5587298	+	555	WP_057021798.1	hypothetical protein	-
FGL41_RS25890	5587369..5587989	+	621	WP_057021760.1	HEPN domain-containing protein	-
FGL41_RS25895	5587991..5589061	+	1071	WP_057021761.1	hypothetical protein	-
FGL41_RS25900	5589129..5589563	+	435	WP_057021762.1	hypothetical protein	-
FGL41_RS25905	5589574..5590095	+	522	WP_057021763.1	hypothetical protein	-
FGL41_RS25910	5590095..5590850	+	756	WP_057021764.1	hypothetical protein	-
FGL41_RS25915	5590908..5591216	+	309	WP_014717392.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FGL41_RS25920	5591213..5591494	+	282	WP_014717391.1	putative addiction module antidote protein	Antitoxin
FGL41_RS25925	5591582..5592412	-	831	WP_138233660.1	hypothetical protein	-
FGL41_RS25930	5592427..5592747	-	321	WP_083348205.1	hypothetical protein	-
FGL41_RS25935	5592824..5593555	-	732	WP_057021799.1	hypothetical protein	-
FGL41_RS25940	5593868..5594560	-	693	WP_057021766.1	SOS response-associated peptidase family protein	-
FGL41_RS25945	5594675..5595790	-	1116	WP_138233661.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	5528477..5734273	205796

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-89)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11532.13 Da
• Isoelectric Point: 9.0774

>T288500 WP_014717392.1 NZ_LR590482:5590908-5591216 [Pseudomonas synxantha]
MNTLITTTEFNQWLKGLKDDRARARIVSRMVSAQEGNFGDCEPVGDGISEMRIFVGPGYRVYYTRRGEVVYLLLCGGDKS
SQKRDIRAAKAILNEIDRGERT

Nucleotide

• Length: 309 bp

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10265.75 Da
• Isoelectric Point: 5.8233

>AT288500 WP_014717391.1 NZ_LR590482:5591213-5591494 [Pseudomonas synxantha]
MTQLKPFEASEYLTNEDTISEFLTASLEDPNPDVFLRALQEVAKARGMSQLARDAGMNRESLYKALAPGAKPRYDTVLKL
VNALGVKLTAQHV

Nucleotide

• Length: 282 bp