Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 3437530..3438143 Replicon chromosome
Accession NZ_LR590482
Organism Pseudomonas synxantha strain NCTC10696

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FGL41_RS15895 Protein ID WP_046072224.1
Coordinates 3437530..3437781 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGL41_RS15900 Protein ID WP_057022619.1
Coordinates 3437778..3438143 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL41_RS15895 3437530..3437781 + 252 WP_046072224.1 type II toxin-antitoxin system HicA family toxin Toxin
FGL41_RS15900 3437778..3438143 + 366 WP_057022619.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGL41_RS15905 3438144..3439316 - 1173 WP_057022620.1 MFS transporter -
FGL41_RS15910 3439448..3440035 + 588 WP_057022621.1 TetR/AcrR family transcriptional regulator -
FGL41_RS15915 3440019..3441374 - 1356 WP_057022622.1 MATE family efflux transporter -
FGL41_RS15920 3441397..3441969 - 573 WP_057022623.1 DUF2239 family protein -
FGL41_RS15925 3442120..3442929 - 810 WP_056846805.1 ammonia-dependent NAD(+) synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9546.13 Da        Isoelectric Point: 10.0941

>T288493 WP_046072224.1 NZ_LR590482:3437530-3437781 [Pseudomonas synxantha]
VSKNEKLLAKLLNEHMAFTWPELVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHRPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13220.07 Da        Isoelectric Point: 6.7403

>AT288493 WP_057022619.1 NZ_LR590482:3437778-3438143 [Pseudomonas synxantha]
VNNQLKHNGYIGSIEASLEDNCLFGKVLFIKALVSYEGKTVAELEAAFREAVDDYLATCHALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALSEFLQHHYPEPCPAIG

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References