Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1363915..1364551 Replicon chromosome
Accession NZ_LR590480
Organism Bordetella parapertussis strain NCTC10522

Toxin (Protein)


Gene name hicA Uniprot ID Q7W5Z1
Locus tag FGL40_RS06405 Protein ID WP_010928914.1
Coordinates 1364369..1364551 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7W5Z0
Locus tag FGL40_RS06400 Protein ID WP_010928915.1
Coordinates 1363915..1364307 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL40_RS06375 1359571..1359997 - 427 Protein_1251 OB-fold domain-containing protein -
FGL40_RS06380 1360001..1361173 - 1173 WP_010928918.1 thiolase domain-containing protein -
FGL40_RS06385 1361240..1361599 - 360 WP_010928917.1 hypothetical protein -
FGL40_RS06390 1361634..1362608 - 975 WP_010928916.1 tripartite tricarboxylate transporter substrate binding protein -
FGL40_RS06395 1362733..1363642 + 910 Protein_1255 LysR family transcriptional regulator -
FGL40_RS06400 1363915..1364307 - 393 WP_010928915.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGL40_RS06405 1364369..1364551 - 183 WP_010928914.1 type II toxin-antitoxin system HicA family toxin Toxin
FGL40_RS06415 1365100..1366320 - 1221 WP_010928912.1 ISL3-like element IS1001 family transposase -
FGL40_RS06425 1366895..1368082 - 1188 WP_010928911.1 MFS transporter -
FGL40_RS06430 1368300..1368977 - 678 WP_010928910.1 HAD-IA family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1365100..1366320 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6572.69 Da        Isoelectric Point: 10.9062

>T288485 WP_010928914.1 NZ_LR590480:c1364551-1364369 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14058.82 Da        Isoelectric Point: 4.2876

>AT288485 WP_010928915.1 NZ_LR590480:c1364307-1363915 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7W5Z1

Antitoxin

Source ID Structure
AlphaFold DB Q7W5Z0

References