Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 807451..808106 Replicon chromosome
Accession NZ_LR590477
Organism Neisseria lactamica strain NCTC10617

Toxin (Protein)


Gene name vapC Uniprot ID D0W9J3
Locus tag FGL10_RS04260 Protein ID WP_003709029.1
Coordinates 807451..807870 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FGL10_RS04265 Protein ID WP_036469701.1
Coordinates 807870..808106 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL10_RS04240 802684..804090 - 1407 WP_036469720.1 MFS transporter -
FGL10_RS04245 804374..805153 + 780 WP_003709035.1 (Fe-S)-binding protein -
FGL10_RS04250 805150..805851 + 702 WP_003709033.1 lactate utilization protein C -
FGL10_RS04255 805848..807302 + 1455 WP_003709031.1 iron-sulfur cluster-binding protein -
FGL10_RS04260 807451..807870 - 420 WP_003709029.1 type II toxin-antitoxin system toxin FitB Toxin
FGL10_RS04265 807870..808106 - 237 WP_036469701.1 antitoxin Antitoxin
FGL10_RS04270 808360..808803 + 444 WP_003709023.1 DNA cytosine methyltransferase -
FGL10_RS04275 808918..809403 - 486 WP_003709019.1 5-(carboxyamino)imidazole ribonucleotide mutase -
FGL10_RS04280 809453..810166 - 714 WP_003709018.1 tol-pal system YbgF family protein -
FGL10_RS04285 810166..810834 - 669 WP_003709017.1 O-methyltransferase -
FGL10_RS04290 810845..811030 - 186 WP_002216929.1 DUF3460 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15455.90 Da        Isoelectric Point: 6.7271

>T288484 WP_003709029.1 NZ_LR590477:c807870-807451 [Neisseria lactamica]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAMTVAELRLGVALLPDGKKKNVLHERLEQSILPLFARRILPFDE
PVAAIYAQIRSYAKTHGKAIAAADGYIAATAKQHRLTVATRDTGPFFAADVAVFNPWYD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8575.68 Da        Isoelectric Point: 5.7998

>AT288484 WP_036469701.1 NZ_LR590477:c808106-807870 [Neisseria lactamica]
MASVVIRNLSESTHNALKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEVDGVELDNVRDFDTKNEVSF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0W9J3

Antitoxin

Source ID Structure

References