Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4501959..4502576 Replicon chromosome
Accession NZ_LR590469
Organism Yersinia enterocolitica subsp. enterocolitica strain NCTC12982

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag FGL26_RS21110 Protein ID WP_002208622.1
Coordinates 4501959..4502162 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6TU35
Locus tag FGL26_RS21115 Protein ID WP_005167670.1
Coordinates 4502208..4502576 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL26_RS21075 4497138..4497476 + 339 WP_002208627.1 P-II family nitrogen regulator -
FGL26_RS21080 4497516..4498805 + 1290 WP_005167660.1 ammonium transporter AmtB -
FGL26_RS21090 4499105..4499968 - 864 WP_005167662.1 acyl-CoA thioesterase II -
FGL26_RS21095 4500226..4500756 + 531 WP_005167665.1 lipoprotein -
FGL26_RS21100 4500808..4501113 - 306 WP_032901164.1 MGMT family protein -
FGL26_RS21110 4501959..4502162 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
FGL26_RS21115 4502208..4502576 - 369 WP_005167670.1 Hha toxicity modulator TomB Antitoxin
FGL26_RS21120 4502734..4503087 - 354 WP_005167672.1 hypothetical protein -
FGL26_RS21130 4503858..4504586 + 729 WP_032902542.1 ABC transporter ATP-binding protein -
FGL26_RS21135 4504583..4505440 + 858 WP_005167676.1 metal ABC transporter permease -
FGL26_RS21140 4505486..4506364 + 879 WP_005167678.1 metal ABC transporter substrate-binding protein -
FGL26_RS21145 4506491..4506634 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
FGL26_RS21150 4506649..4506909 - 261 WP_005163438.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T288482 WP_002208622.1 NZ_LR590469:c4502162-4501959 [Yersinia enterocolitica subsp. enterocolitica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14134.86 Da        Isoelectric Point: 4.4085

>AT288482 WP_005167670.1 NZ_LR590469:c4502576-4502208 [Yersinia enterocolitica subsp. enterocolitica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6L1C1

References