Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3928780..3929281 Replicon chromosome
Accession NZ_LR590469
Organism Yersinia enterocolitica subsp. enterocolitica strain NCTC12982

Toxin (Protein)


Gene name relE Uniprot ID A0A8B6L013
Locus tag FGL26_RS18625 Protein ID WP_005175262.1
Coordinates 3929024..3929281 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A1JJ37
Locus tag FGL26_RS18620 Protein ID WP_005175264.1
Coordinates 3928780..3929034 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL26_RS18590 3924133..3925203 + 1071 WP_005175277.1 LPS export ABC transporter permease LptG -
FGL26_RS18600 3925874..3927133 + 1260 Protein_3522 integrase arm-type DNA-binding domain-containing protein -
FGL26_RS18605 3927268..3927582 - 315 WP_005175269.1 BrnA antitoxin family protein -
FGL26_RS18610 3927569..3927850 - 282 WP_005175267.1 BrnT family toxin -
FGL26_RS18620 3928780..3929034 + 255 WP_005175264.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FGL26_RS18625 3929024..3929281 + 258 WP_005175262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL26_RS18630 3929493..3929843 - 351 Protein_3527 transcriptional regulator -
FGL26_RS18635 3929848..3930210 + 363 Protein_3528 hypothetical protein -
FGL26_RS18640 3930571..3930981 + 411 WP_005159173.1 GNAT family N-acetyltransferase -
FGL26_RS18645 3931007..3931696 + 690 WP_005175259.1 PAS and helix-turn-helix domain-containing protein -
FGL26_RS18650 3931733..3933040 + 1308 WP_005175249.1 cytosine permease -
FGL26_RS18655 3933090..3933675 + 586 Protein_3532 HEAT repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10105.79 Da        Isoelectric Point: 8.0296

>T288481 WP_005175262.1 NZ_LR590469:3929024-3929281 [Yersinia enterocolitica subsp. enterocolitica]
MTFNIDFDERALKEWHKLDKAIREQFKKKLRKLQENPYIESARLHGDLAGCFKIKLRASGFRLIYQVIDEEIVIWIVAVG
KLEDE

Download         Length: 258 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9680.07 Da        Isoelectric Point: 4.8283

>AT288481 WP_005175264.1 NZ_LR590469:3928780-3929034 [Yersinia enterocolitica subsp. enterocolitica]
MSTIQIRVDDELKKSAYQAFEKLNLSPSDALRLFLRYVAENEKLPFSEVSVMVSNQDEDADILAVVRERLKNPAKRIRVN
IDDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B6L013

Antitoxin

Source ID Structure
AlphaFold DB A1JJ37

References