Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3966155..3966811 Replicon chromosome
Accession NC_020211
Organism Serratia marcescens WW4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SMWW4_RS18510 Protein ID WP_015378740.1
Coordinates 3966155..3966544 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag SMWW4_RS18515 Protein ID WP_004941563.1
Coordinates 3966548..3966811 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMWW4_RS18495 3962622..3964052 + 1431 WP_015378738.1 multidrug transporter subunit MdtD -
SMWW4_RS18500 3964049..3965431 + 1383 WP_004941570.1 two-component system sensor histidine kinase BaeS -
SMWW4_RS18505 3965431..3966147 + 717 WP_015378739.1 two-component system response regulator BaeR -
SMWW4_RS18510 3966155..3966544 - 390 WP_015378740.1 type II toxin-antitoxin system VapC family toxin Toxin
SMWW4_RS18515 3966548..3966811 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMWW4_RS18520 3967149..3967487 + 339 WP_004941561.1 YegP family protein -
SMWW4_RS18525 3967666..3969018 + 1353 WP_004941558.1 tRNA 5-hydroxyuridine modification protein YegQ -
SMWW4_RS18530 3969486..3970391 + 906 WP_015378742.1 lipid kinase YegS -
SMWW4_RS18535 3970560..3971774 + 1215 WP_015378743.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14474.73 Da        Isoelectric Point: 8.4843

>T28848 WP_015378740.1 NC_020211:c3966544-3966155 [Serratia marcescens WW4]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPYAVCISSVTEAELRYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T28848 NC_020211:c3966544-3966155 [Serratia marcescens WW4]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTATGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCGTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGAGAGAAAGGGCAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT28848 WP_004941563.1 NC_020211:c3966811-3966548 [Serratia marcescens WW4]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT28848 NC_020211:c3966811-3966548 [Serratia marcescens WW4]
ATGGAAAGGATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCCGACCGC
GATCCCTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References