Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2858811..2860440 Replicon chromosome
Accession NZ_LR590469
Organism Yersinia enterocolitica subsp. enterocolitica strain NCTC12982

Toxin (Protein)


Gene name hipA Uniprot ID A0A8B6KYH1
Locus tag FGL26_RS13605 Protein ID WP_005174384.1
Coordinates 2859112..2860440 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A8B6KW50
Locus tag FGL26_RS13600 Protein ID WP_005174382.1
Coordinates 2858811..2859110 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL26_RS13585 2854164..2855813 - 1650 WP_005174376.1 Na+/H+ antiporter -
FGL26_RS13590 2856028..2857395 - 1368 WP_005174378.1 NCS2 family permease -
FGL26_RS13595 2857871..2858542 - 672 WP_005174380.1 glutathione S-transferase -
FGL26_RS13600 2858811..2859110 + 300 WP_005174382.1 helix-turn-helix transcriptional regulator Antitoxin
FGL26_RS13605 2859112..2860440 + 1329 WP_005174384.1 type II toxin-antitoxin system HipA family toxin Toxin
FGL26_RS13610 2860505..2861056 - 552 WP_005174387.1 single-stranded DNA-binding protein SSB1 -
FGL26_RS13615 2861456..2864287 + 2832 WP_005174389.1 excinuclease ABC subunit UvrA -
FGL26_RS13620 2864346..2864699 - 354 WP_005165225.1 MmcQ/YjbR family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49856.68 Da        Isoelectric Point: 6.7708

>T288479 WP_005174384.1 NZ_LR590469:2859112-2860440 [Yersinia enterocolitica subsp. enterocolitica]
MARRIQRLNIWMNGQHVGYWEKNRGEESLTYAQEWLANEQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATKYHADSINPFDLLFELGRDCVGAIQLLTDDAPPSDLFSIQQQPLTESDVARILRNSLSDNAFVRPEHDEDLRLSIAGA
QEKTALLFHDNRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVASCEIGQFEDQKALIVERF
DRRLSNDSRWIVRLPQEDMCQATGTSPLKKYQTDGGPGITTIMEILSGSDNASEDRKVFFKAQIIFWLLAATDGHAKNFS
ITHLPANHYHLTPLYDVLSTHPIIGAGRNQIAAQKTKLAMAVRGSKNYYLINQIQRRHWRKQAEIVGLGAAQADSIIDEI
ITATPRVITQIQARLPANFPTDLAESILTGLHRQCEKIAAMP

Download         Length: 1329 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11247.95 Da        Isoelectric Point: 9.5949

>AT288479 WP_005174382.1 NZ_LR590469:2858811-2859110 [Yersinia enterocolitica subsp. enterocolitica]
MDYPIKILSQLRPTLIGFRKNKGLTQANLAQLLGITQQSYAKLEADPTSASIERLFKVLQLLDVELILGEKKNARPHPNK
THQPEQSQTIDLPSKQEDW

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B6KYH1

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6KW50

References