Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2438512..2439184 Replicon chromosome
Accession NZ_LR590469
Organism Yersinia enterocolitica subsp. enterocolitica strain NCTC12982

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag FGL26_RS11620 Protein ID WP_005166047.1
Coordinates 2438512..2438937 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag FGL26_RS11625 Protein ID WP_004390965.1
Coordinates 2438918..2439184 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL26_RS11600 2434286..2434804 + 519 WP_005173454.1 flavodoxin FldB -
FGL26_RS11605 2434863..2436284 - 1422 WP_005173463.1 cell envelope integrity protein CreD -
FGL26_RS11610 2436376..2437803 - 1428 WP_032909123.1 two-component system sensor histidine kinase CreC -
FGL26_RS11615 2437814..2438512 - 699 WP_005173478.1 two-component system response regulator CreB -
FGL26_RS11620 2438512..2438937 - 426 WP_005166047.1 protein YgfX Toxin
FGL26_RS11625 2438918..2439184 - 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
FGL26_RS11630 2439579..2440571 + 993 WP_005173484.1 tRNA-modifying protein YgfZ -
FGL26_RS11635 2440625..2441308 - 684 WP_005173485.1 hemolysin III family protein -
FGL26_RS11640 2441539..2442141 + 603 WP_005173488.1 HD domain-containing protein -
FGL26_RS11645 2442154..2442288 - 135 Protein_2210 SDR family oxidoreductase -
FGL26_RS11650 2442327..2442764 - 438 WP_005173494.1 lipocalin-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T288478 WP_005166047.1 NZ_LR590469:c2438937-2438512 [Yersinia enterocolitica subsp. enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT288478 WP_004390965.1 NZ_LR590469:c2439184-2438918 [Yersinia enterocolitica subsp. enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References