Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3869886..3870448 Replicon chromosome
Accession NC_020211
Organism Serratia marcescens WW4

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag SMWW4_RS18085 Protein ID WP_015378688.1
Coordinates 3869886..3870242 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag SMWW4_RS18090 Protein ID WP_004936539.1
Coordinates 3870239..3870448 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMWW4_RS18065 3865622..3866419 - 798 WP_015378684.1 energy transducer TonB -
SMWW4_RS18070 3866522..3867361 - 840 WP_015378685.1 ChaN family lipoprotein -
SMWW4_RS18075 3867539..3868948 + 1410 WP_015378686.1 S-methylmethionine permease -
SMWW4_RS18080 3868938..3869876 + 939 WP_015378687.1 homocysteine S-methyltransferase -
SMWW4_RS18085 3869886..3870242 - 357 WP_015378688.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SMWW4_RS18090 3870239..3870448 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SMWW4_RS18095 3870558..3872837 - 2280 WP_004936542.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
SMWW4_RS25835 3873052..3873225 - 174 WP_021505636.1 hypothetical protein -
SMWW4_RS18105 3873206..3873586 - 381 WP_015378689.1 DUF2570 family protein -
SMWW4_RS18110 3873583..3873984 - 402 WP_015378690.1 M15 family metallopeptidase -
SMWW4_RS18115 3873974..3874300 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13162.90 Da        Isoelectric Point: 4.9139

>T28847 WP_015378688.1 NC_020211:c3870242-3869886 [Serratia marcescens WW4]
MIFLTAEDIAEFNAEIVPHGRQEGNKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T28847 NC_020211:c3870242-3869886 [Serratia marcescens WW4]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAACGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAACAAAGT
TGAGGCTGCCGCCAACCGCGTGCTCAATGCTTACCACTATGAGAACGTCACCGACGTTTACCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAATAAGCGCACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCCCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACATTTACGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT28847 WP_004936539.1 NC_020211:c3870448-3870239 [Serratia marcescens WW4]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT28847 NC_020211:c3870448-3870239 [Serratia marcescens WW4]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCTAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References