288467

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 269325..269937 Replicon chromosome
Accession NZ_LR590466
Organism Streptococcus pyogenes strain NCTC8193

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag FGK81_RS01320 Protein ID WP_002982731.1
Coordinates 269325..269660 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag FGK81_RS01325 Protein ID WP_002988079.1
Coordinates 269650..269937 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK81_RS01285 264675..265193 + 519 WP_011889154.1 NYN domain-containing protein -
FGK81_RS01290 265290..266150 + 861 WP_011889153.1 DegV family protein -
FGK81_RS01295 266286..266792 + 507 WP_002988070.1 hypothetical protein -
FGK81_RS01300 266789..266995 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
FGK81_RS01305 267213..267659 + 447 WP_002982710.1 50S ribosomal protein L13 -
FGK81_RS01310 267680..268072 + 393 WP_002982716.1 30S ribosomal protein S9 -
FGK81_RS09905 268192..268740 - 549 WP_136115776.1 site-specific integrase -
FGK81_RS09910 268703..269173 - 471 WP_021733374.1 site-specific integrase -
FGK81_RS01320 269325..269660 - 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGK81_RS01325 269650..269937 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
FGK81_RS01330 270587..271360 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
FGK81_RS01335 271806..272234 + 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
FGK81_RS01340 272269..272784 + 516 WP_011889152.1 galactose-6-phosphate isomerase subunit LacB -
FGK81_RS01345 272832..273761 + 930 WP_011889151.1 tagatose-6-phosphate kinase -
FGK81_RS01350 273765..274748 + 984 WP_011889150.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T288467 WP_002982731.1 NZ_LR590466:c269660-269325 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT288467 WP_002988079.1 NZ_LR590466:c269937-269650 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References