288465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 326271..326745 Replicon chromosome
Accession NZ_LR590465
Organism Haemophilus influenzae strain NCTC8468

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag FGK83_RS01635 Protein ID WP_197733310.1
Coordinates 326271..326456 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag FGK83_RS01640 Protein ID WP_005650837.1
Coordinates 326449..326745 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK83_RS01630 323021..326128 + 3108 WP_171007148.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
FGK83_RS01635 326271..326456 + 186 WP_197733310.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGK83_RS01640 326449..326745 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
FGK83_RS01645 326929..328845 + 1917 WP_138171502.1 ABC transporter ATP-binding protein -
FGK83_RS01650 328855..329391 + 537 WP_138171503.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
FGK83_RS01655 329407..329958 + 552 WP_138171504.1 Sua5/YciO/YrdC/YwlC family protein -
FGK83_RS01660 329962..330768 + 807 WP_138171505.1 shikimate dehydrogenase -
FGK83_RS01665 330780..331532 + 753 WP_048951646.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-51)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7462.80 Da        Isoelectric Point: 11.0200

>T288465 WP_197733310.1 NZ_LR590465:326271-326456 [Haemophilus influenzae]
ILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 186 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT288465 WP_005650837.1 NZ_LR590465:326449-326745 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References