Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 242243..242847 Replicon chromosome
Accession NZ_LR590465
Organism Haemophilus influenzae strain NCTC8468

Toxin (Protein)


Gene name relE Uniprot ID Q9S658
Locus tag FGK83_RS01240 Protein ID WP_042593918.1
Coordinates 242539..242847 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FGK83_RS01235 Protein ID WP_138171472.1
Coordinates 242243..242539 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK83_RS01220 238009..239394 + 1386 WP_138171470.1 L-seryl-tRNA(Sec) selenium transferase -
FGK83_RS01225 239391..241250 + 1860 WP_138171471.1 selenocysteine-specific translation elongation factor -
FGK83_RS01230 241269..242123 + 855 WP_050823021.1 DUF3298 domain-containing protein -
FGK83_RS01235 242243..242539 + 297 WP_138171472.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FGK83_RS01240 242539..242847 + 309 WP_042593918.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FGK83_RS01245 242904..246110 - 3207 WP_138171473.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
FGK83_RS01250 246440..247738 + 1299 WP_138171474.1 trigger factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11921.67 Da        Isoelectric Point: 7.2393

>T288463 WP_042593918.1 NZ_LR590465:242539-242847 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10984.23 Da        Isoelectric Point: 4.2837

>AT288463 WP_138171472.1 NZ_LR590465:242243-242539 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLHPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9S658

Antitoxin

Source ID Structure

References