Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 180080..180558 Replicon chromosome
Accession NZ_LR590465
Organism Haemophilus influenzae strain NCTC8468

Toxin (Protein)


Gene name VapD Uniprot ID A0A0K9L551
Locus tag FGK83_RS00930 Protein ID WP_050848517.1
Coordinates 180080..180358 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag FGK83_RS00935 Protein ID WP_012055040.1
Coordinates 180367..180558 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK83_RS00910 175270..176940 - 1671 WP_138171441.1 fructose-specific PTS transporter subunit EIIC -
FGK83_RS00915 176942..177883 - 942 WP_138171442.1 1-phosphofructokinase -
FGK83_RS00920 177885..179384 - 1500 WP_138171443.1 fused PTS fructose transporter subunit IIA/HPr protein -
FGK83_RS00925 179454..179984 - 531 WP_162632261.1 hypothetical protein -
FGK83_RS00930 180080..180358 - 279 WP_050848517.1 virulence-associated protein VapD Toxin
FGK83_RS00935 180367..180558 - 192 WP_012055040.1 DUF5397 family protein Antitoxin
FGK83_RS00940 180629..181927 - 1299 WP_050846548.1 hemolysin family protein -
FGK83_RS00945 181978..182502 - 525 WP_005669286.1 DUF1523 family protein -
FGK83_RS00950 182529..183311 - 783 WP_138171444.1 YchF/TatD family DNA exonuclease -
FGK83_RS00955 183350..184330 - 981 WP_138171445.1 DNA polymerase III subunit delta' -
FGK83_RS00960 184327..184959 - 633 WP_171007187.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10604.98 Da        Isoelectric Point: 5.7408

>T288462 WP_050848517.1 NZ_LR590465:c180358-180080 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNSLKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT288462 WP_012055040.1 NZ_LR590465:c180558-180367 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9L551

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References