Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4648794..4649310 Replicon chromosome
Accession NZ_LR588412
Organism Klebsiella pneumoniae strain NCTC9157

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag FGL27_RS22745 Protein ID WP_009309309.1
Coordinates 4648794..4649078 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FGL27_RS22750 Protein ID WP_002886901.1
Coordinates 4649068..4649310 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL27_RS22725 4644270..4644578 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
FGL27_RS26295 4644663..4644836 + 174 WP_032408826.1 hypothetical protein -
FGL27_RS22730 4644839..4645582 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FGL27_RS22735 4645939..4648077 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
FGL27_RS22740 4648326..4648790 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FGL27_RS22745 4648794..4649078 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL27_RS22750 4649068..4649310 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FGL27_RS22755 4649388..4651298 - 1911 WP_004152270.1 BglG family transcription antiterminator -
FGL27_RS22760 4651321..4652475 - 1155 WP_004178372.1 lactonase family protein -
FGL27_RS22765 4652542..4653282 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T288460 WP_009309309.1 NZ_LR588412:c4649078-4648794 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT288460 WP_002886901.1 NZ_LR588412:c4649310-4649068 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References