Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2562600..2564188 Replicon chromosome
Accession NZ_LR588412
Organism Klebsiella pneumoniae strain NCTC9157

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag FGL27_RS12635 Protein ID WP_002904792.1
Coordinates 2562600..2563922 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag FGL27_RS12640 Protein ID WP_002904790.1
Coordinates 2563922..2564188 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL27_RS12620 2560088..2561093 + 1006 Protein_2450 type 1 fimbrial protein -
FGL27_RS12630 2561291..2562583 + 1293 WP_032423495.1 glycoside hydrolase family 10 protein -
FGL27_RS12635 2562600..2563922 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
FGL27_RS12640 2563922..2564188 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
FGL27_RS12645 2564454..2564780 - 327 WP_004176200.1 hydroxyisourate hydrolase -
FGL27_RS12650 2564777..2565277 - 501 WP_064151579.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
FGL27_RS12655 2565255..2566634 - 1380 WP_004199850.1 purine permease -
FGL27_RS12660 2566980..2568134 + 1155 WP_025861919.1 FAD-dependent urate hydroxylase HpxO -
FGL27_RS12665 2568115..2569038 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T288456 WP_002904792.1 NZ_LR588412:c2563922-2562600 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT288456 WP_002904790.1 NZ_LR588412:c2564188-2563922 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References