Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3175547..3176175 Replicon chromosome
Accession NC_020211
Organism Serratia marcescens WW4

Toxin (Protein)


Gene name hicA Uniprot ID A0A0P0QK57
Locus tag SMWW4_RS25015 Protein ID WP_015378230.1
Coordinates 3175547..3175750 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A086GDG8
Locus tag SMWW4_RS14795 Protein ID WP_015378231.1
Coordinates 3175762..3176175 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMWW4_RS14790 3171412..3175383 + 3972 WP_015378229.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
SMWW4_RS25015 3175547..3175750 + 204 WP_015378230.1 type II toxin-antitoxin system HicA family toxin Toxin
SMWW4_RS14795 3175762..3176175 + 414 WP_015378231.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SMWW4_RS14800 3176205..3176957 - 753 WP_015378232.1 L-cystine ABC transporter ATP-binding protein YecC -
SMWW4_RS14805 3176961..3177623 - 663 WP_015378233.1 cystine ABC transporter permease -
SMWW4_RS14810 3177623..3178423 - 801 WP_015378234.1 cystine ABC transporter substrate-binding protein -
SMWW4_RS14815 3178539..3179531 - 993 WP_015378235.1 D-cysteine desulfhydrase -
SMWW4_RS14820 3179656..3180165 - 510 WP_004934751.1 flagella biosynthesis regulatory protein FliZ -
SMWW4_RS14825 3180220..3180942 - 723 WP_004934752.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliZ / fliA / fliS 3158347..3187259 28912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7523.89 Da        Isoelectric Point: 11.1475

>T28845 WP_015378230.1 NC_020211:3175547-3175750 [Serratia marcescens WW4]
VKSSELIALLESHGWVLRRVKGSHHQFKHPDFALIITVPHPKKDLKLGTLRQILKDAGLSALHIATR

Download         Length: 204 bp

>T28845 NC_020211:3175547-3175750 [Serratia marcescens WW4]
GTGAAGAGTTCAGAACTGATTGCGCTGCTGGAAAGCCACGGTTGGGTATTGCGGCGGGTAAAAGGCAGCCACCATCAATT
CAAACATCCCGATTTTGCGCTGATCATCACCGTGCCGCATCCAAAGAAAGATCTCAAGCTGGGCACGCTGCGGCAGATAC
TTAAAGACGCGGGGTTAAGTGCGCTTCACATCGCCACGCGTTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14888.63 Da        Isoelectric Point: 5.4867

>AT28845 WP_015378231.1 NC_020211:3175762-3176175 [Serratia marcescens WW4]
MFYPAYIHTESNGSASGFFPDVPGCYFAGTSLDDAFADAQSALDAHFELLSEDNQPLPRPHAVAAHLAKDAGSFEGGQWL
LVAINMDKFDGRAERINITLPHRLLSRIDSLVRQHPGYGSRSGFLAAAARNELLKAE

Download         Length: 414 bp

>AT28845 NC_020211:3175762-3176175 [Serratia marcescens WW4]
ATGTTTTATCCCGCTTATATCCATACAGAATCAAACGGCAGCGCCAGCGGTTTCTTTCCCGACGTCCCTGGCTGCTACTT
CGCCGGCACCAGCCTGGACGACGCTTTTGCCGATGCCCAAAGCGCACTGGACGCGCACTTTGAGTTGTTGAGCGAAGACA
ATCAACCGCTACCGCGCCCGCATGCCGTCGCAGCCCATCTTGCCAAAGATGCGGGATCCTTCGAGGGAGGACAATGGCTA
TTGGTCGCTATCAATATGGATAAATTTGACGGCCGAGCCGAACGGATTAACATCACGTTGCCCCATCGCCTGTTAAGTCG
CATTGACTCTCTGGTTCGGCAACATCCGGGATACGGCAGCCGCAGCGGATTTCTCGCTGCCGCCGCGCGCAATGAATTGT
TGAAAGCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QK57

Antitoxin

Source ID Structure
AlphaFold DB A0A086GDG8

References