Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4240505..4242093 Replicon chromosome
Accession NZ_LR588411
Organism Klebsiella quasipneumoniae strain NCTC9170

Toxin (Protein)


Gene name hipA Uniprot ID A0A5Q9LEV0
Locus tag FGL28_RS20660 Protein ID WP_043519554.1
Coordinates 4240771..4242093 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag FGL28_RS20655 Protein ID WP_004205921.1
Coordinates 4240505..4240771 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL28_RS20630 4235638..4236561 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
FGL28_RS20635 4236542..4237696 - 1155 WP_004205928.1 FAD-dependent urate hydroxylase HpxO -
FGL28_RS20640 4238042..4239421 + 1380 WP_122543002.1 purine permease -
FGL28_RS20645 4239399..4239899 + 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
FGL28_RS20650 4239896..4240222 + 327 WP_122543000.1 hydroxyisourate hydrolase -
FGL28_RS20655 4240505..4240771 + 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
FGL28_RS20660 4240771..4242093 + 1323 WP_043519554.1 type II toxin-antitoxin system HipA family toxin Toxin
FGL28_RS20665 4242110..4243402 - 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
FGL28_RS20675 4243544..4243750 - 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
FGL28_RS20680 4243753..4244286 - 534 WP_004205916.1 hypothetical protein -
FGL28_RS20685 4244315..4244659 - 345 WP_004205915.1 hypothetical protein -
FGL28_RS20690 4244646..4245761 - 1116 WP_049115414.1 serine hydrolase -
FGL28_RS20695 4246030..4246812 - 783 WP_122542998.1 type I methionyl aminopeptidase -
FGL28_RS20700 4246793..4247011 - 219 WP_002904808.1 ParD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48998.30 Da        Isoelectric Point: 8.2655

>T288444 WP_043519554.1 NZ_LR588411:4240771-4242093 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT288444 WP_004205921.1 NZ_LR588411:4240505-4240771 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LEV0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References