Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2200694..2201207 Replicon chromosome
Accession NZ_LR588411
Organism Klebsiella quasipneumoniae strain NCTC9170

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag FGL28_RS10780 Protein ID WP_017900571.1
Coordinates 2200926..2201207 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FGL28_RS10775 Protein ID WP_002886901.1
Coordinates 2200694..2200936 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL28_RS10760 2196724..2197464 + 741 WP_004206507.1 KDGP aldolase family protein -
FGL28_RS10765 2197532..2198683 + 1152 WP_017900573.1 lactonase family protein -
FGL28_RS10770 2198706..2200616 + 1911 WP_004206509.1 BglG family transcription antiterminator -
FGL28_RS10775 2200694..2200936 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FGL28_RS10780 2200926..2201207 + 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL28_RS10785 2201211..2201675 - 465 WP_032456904.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FGL28_RS10790 2201974..2202285 - 312 WP_109938332.1 hypothetical protein -
FGL28_RS10795 2202412..2204550 - 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T288442 WP_017900571.1 NZ_LR588411:2200926-2201207 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT288442 WP_002886901.1 NZ_LR588411:2200694-2200936 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663BE04

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References