Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876299..876956 Replicon chromosome
Accession NZ_LR588411
Organism Klebsiella quasipneumoniae strain NCTC9170

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag FGL28_RS04270 Protein ID WP_004205323.1
Coordinates 876299..876709 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FGL28_RS04275 Protein ID WP_002916312.1
Coordinates 876690..876956 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL28_RS04250 872299..874032 - 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -
FGL28_RS04255 874038..874751 - 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FGL28_RS04260 874774..875670 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FGL28_RS04265 875771..876292 + 522 WP_004205324.1 flavodoxin FldB -
FGL28_RS04270 876299..876709 - 411 WP_004205323.1 protein YgfX Toxin
FGL28_RS04275 876690..876956 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FGL28_RS04280 877202..878185 + 984 WP_122542307.1 tRNA-modifying protein YgfZ -
FGL28_RS04285 878284..878943 - 660 WP_004205319.1 hemolysin III family protein -
FGL28_RS04290 879106..879417 - 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
FGL28_RS04295 879467..880195 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
FGL28_RS04300 880314..881747 + 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T288441 WP_004205323.1 NZ_LR588411:c876709-876299 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT288441 WP_002916312.1 NZ_LR588411:c876956-876690 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References