Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 130988..132780 Replicon chromosome
Accession NZ_LR588411
Organism Klebsiella quasipneumoniae strain NCTC9170

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FGL28_RS00565 Protein ID WP_122543299.1
Coordinates 130988..132337 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FGL28_RS00570 Protein ID WP_122543288.1
Coordinates 132334..132780 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL28_RS00540 126474..127406 - 933 WP_014907191.1 tRNA dihydrouridine(16) synthase DusC -
FGL28_RS00545 127764..128168 + 405 WP_004201620.1 CidA/LrgA family protein -
FGL28_RS00550 128158..128853 + 696 WP_004201621.1 CidB/LrgB family autolysis modulator -
FGL28_RS00555 128982..129866 + 885 WP_004201623.1 cytidine deaminase -
FGL28_RS00560 130142..130873 + 732 WP_008804033.1 outer membrane permeability protein SanA -
FGL28_RS00565 130988..132337 + 1350 WP_122543299.1 type II toxin-antitoxin system HipA family toxin Toxin
FGL28_RS00570 132334..132780 + 447 WP_122543288.1 helix-turn-helix domain-containing protein Antitoxin
FGL28_RS00575 132822..133832 - 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
FGL28_RS00580 133848..135368 - 1521 WP_004201625.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
FGL28_RS00585 135487..136485 - 999 WP_004201626.1 galactose/glucose ABC transporter substrate-binding protein MglB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(166-410)

Antitoxin

(78-132)


Sequences


Toxin        


Download         Length: 450 a.a.        Molecular weight: 51020.92 Da        Isoelectric Point: 4.8038

>T288440 WP_122543299.1 NZ_LR588411:130988-132337 [Klebsiella quasipneumoniae]
METLTVQAFLNAEWQDIALIKFPGSEQGDWFTTQIDYLTDYAIDFLERDDYHAVSLNHPVSLYFEDHGNPGWLRFIDDII
PSGASRRYWVNFLDISELPQGQQNFILLKFGTMSPVGNLRIKDSVPDWDSLASSKTFSVTDVMNRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSKRQEIWIDTWQNEPGSDDLYYLVKYPRGSRSEVDCNILRAEFHYYHELTAMGFSTIPVDNMR
LEEGLHYPSLWLPRFDIRRDGDGRIMRLGMESVYSLLQKAPATILDHETTLRILIEKIASSHMVRVQNYRFDVQGFIIDW
VRRDLLNIIFGNSDNHGRNTAFMKADNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDT
LLNALRETASQLIDLPSRLKARGVPVQILEMPSIGFKFIPDKLARWGLL

Download         Length: 1350 bp


Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16538.25 Da        Isoelectric Point: 10.5137

>AT288440 WP_122543288.1 NZ_LR588411:132334-132780 [Klebsiella quasipneumoniae]
MKTLNKKETEIQNTLARLRAENPPSLPATEVTATEKKARSEISRQRVSTGLKKVKTIDRQVVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIFKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References