Detailed information of TA system TA288438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4838704..4840202
• Replicon: chromosome
• Accession: NZ_LR588408
• Organism: Klebsiella pneumoniae strain NCTC11698

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: FGL30_RS23520
• Protein ID: WP_052455087.1
• Coordinates: 4838704..4839438 (-)
• Length: 245 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: FGL30_RS23525
• Protein ID: WP_040240384.1
• Coordinates: 4839444..4840202 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL30_RS23500	4833827..4835347	+	1521	WP_040240391.1	sugar ABC transporter ATP-binding protein	-
FGL30_RS23505	4835344..4836342	+	999	WP_002885172.1	ribose ABC transporter permease	-
FGL30_RS23510	4836373..4837314	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
FGL30_RS23515	4837389..4838396	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
FGL30_RS23520	4838704..4839438	-	735	WP_052455087.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FGL30_RS23525	4839444..4840202	-	759	WP_040240384.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
FGL30_RS23530	4840288..4841016	-	729	WP_002885152.1	response regulator transcription factor	-
FGL30_RS23535	4841289..4843436	+	2148	WP_077598921.1	formate dehydrogenase subunit alpha	-
FGL30_RS23540	4843666..4844352	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-211)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 245 a.a.
• Molecular weight: 27349.61 Da
• Isoelectric Point: 4.9562

>T288438 WP_052455087.1 NZ_LR588408:c4839438-4838704 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQ

Nucleotide

• Length: 735 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT288438 WP_040240384.1 NZ_LR588408:c4840202-4839444 [Klebsiella pneumoniae]
MSTKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp