Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4672283..4672799 Replicon chromosome
Accession NZ_LR588408
Organism Klebsiella pneumoniae strain NCTC11698

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FGL30_RS22695 Protein ID WP_040240475.1
Coordinates 4672283..4672567 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FGL30_RS22700 Protein ID WP_002886901.1
Coordinates 4672557..4672799 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL30_RS22675 4667679..4667987 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
FGL30_RS26415 4668072..4668245 + 174 WP_002886906.1 hypothetical protein -
FGL30_RS22680 4668248..4668991 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FGL30_RS22685 4669348..4671486 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FGL30_RS22690 4671815..4672279 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FGL30_RS22695 4672283..4672567 - 285 WP_040240475.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL30_RS22700 4672557..4672799 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FGL30_RS22705 4672877..4674787 - 1911 WP_004152270.1 BglG family transcription antiterminator -
FGL30_RS22710 4674810..4675964 - 1155 WP_023159544.1 lactonase family protein -
FGL30_RS22715 4676031..4676771 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11186.00 Da        Isoelectric Point: 10.3787

>T288437 WP_040240475.1 NZ_LR588408:c4672567-4672283 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKTAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT288437 WP_002886901.1 NZ_LR588408:c4672799-4672557 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References