Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4127232..4127985 Replicon chromosome
Accession NZ_LR588408
Organism Klebsiella pneumoniae strain NCTC11698

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag FGL30_RS20180 Protein ID WP_071988264.1
Coordinates 4127617..4127985 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FGL30_RS20175 Protein ID WP_040240827.1
Coordinates 4127232..4127582 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL30_RS20145 4122409..4123560 - 1152 WP_135728469.1 hypothetical protein -
FGL30_RS20150 4123658..4124551 + 894 WP_040240820.1 50S ribosome-binding GTPase -
FGL30_RS20155 4124836..4125513 + 678 WP_040240822.1 hypothetical protein -
FGL30_RS20160 4125609..4126430 + 822 WP_040240874.1 DUF945 domain-containing protein -
FGL30_RS20165 4126501..4126974 + 474 WP_040240824.1 DNA repair protein RadC -
FGL30_RS20170 4126990..4127211 + 222 WP_040240825.1 DUF987 domain-containing protein -
FGL30_RS20175 4127232..4127582 + 351 WP_040240827.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FGL30_RS20180 4127617..4127985 + 369 WP_071988264.1 TA system toxin CbtA family protein Toxin
FGL30_RS20190 4128615..4131260 - 2646 WP_004213871.1 AcoK -
FGL30_RS20195 4131634..4132593 + 960 WP_012737450.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13824.97 Da        Isoelectric Point: 8.2789

>T288435 WP_071988264.1 NZ_LR588408:4127617-4127985 [Klebsiella pneumoniae]
MNTLPAINQRAVQTCLSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKRHIEAGITLVDAVNFLVEKYELIRIDRRGF
SSQGQVPYLTVTDILHARRACGLTNSCPYREVSNIVLSRSRQ

Download         Length: 369 bp

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13045.95 Da        Isoelectric Point: 7.2638

>AT288435 WP_040240827.1 NZ_LR588408:4127232-4127582 [Klebsiella pneumoniae]
MSSKTLTVNDDTTEPWWGLNRNVIPCFGARLVQEGNRLHYLSDRANIIGLFNKADLLRLDQAFPVLLKQAELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSCGHVYISIYPTQR

Download         Length: 351 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References