Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2632442..2634030 Replicon chromosome
Accession NZ_LR588408
Organism Klebsiella pneumoniae strain NCTC11698

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FGL30_RS12955 Protein ID WP_040241872.1
Coordinates 2632442..2633764 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag FGL30_RS12960 Protein ID WP_002904790.1
Coordinates 2633764..2634030 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL30_RS12935 2627498..2629999 + 2502 WP_117242827.1 fimbrial biogenesis outer membrane usher protein -
FGL30_RS12940 2629987..2630991 + 1005 WP_040241874.1 type 1 fimbrial protein -
FGL30_RS12950 2631133..2632425 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
FGL30_RS12955 2632442..2633764 - 1323 WP_040241872.1 type II toxin-antitoxin system HipA family toxin Toxin
FGL30_RS12960 2633764..2634030 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
FGL30_RS12965 2634296..2634622 - 327 WP_004176200.1 hydroxyisourate hydrolase -
FGL30_RS12970 2634619..2635119 - 501 WP_040241869.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
FGL30_RS12975 2635097..2636476 - 1380 WP_004176204.1 purine permease -
FGL30_RS12980 2636822..2637976 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
FGL30_RS12985 2637957..2638880 - 924 WP_023316845.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49144.48 Da        Isoelectric Point: 7.5357

>T288432 WP_040241872.1 NZ_LR588408:c2633764-2632442 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVYFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT288432 WP_002904790.1 NZ_LR588408:c2634030-2633764 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References