Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1492963..1493625 Replicon chromosome
Accession NZ_LR536843
Organism Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E0F34_RS08120 Protein ID WP_000192221.1
Coordinates 1493452..1493625 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag E0F34_RS08115 Protein ID WP_000961810.1
Coordinates 1492963..1493415 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F34_RS08090 1488853..1489596 - 744 WP_001188206.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
E0F34_RS08095 1489598..1490548 - 951 WP_078170518.1 50S ribosomal protein L11 methyltransferase -
E0F34_RS08100 1490686..1491114 - 429 WP_061649866.1 NUDIX hydrolase -
E0F34_RS08105 1491095..1492183 - 1089 WP_050966590.1 M50 family metallopeptidase -
E0F34_RS08110 1492202..1492672 - 471 WP_000257097.1 DUF3013 family protein -
E0F34_RS08115 1492963..1493415 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E0F34_RS08120 1493452..1493625 - 174 WP_000192221.1 type II toxin-antitoxin system HicA family toxin Toxin
E0F34_RS08125 1493768..1494016 - 249 WP_000797237.1 hypothetical protein -
E0F34_RS08130 1494006..1494221 - 216 WP_075329187.1 hypothetical protein -
E0F34_RS08135 1494519..1495790 + 1272 WP_130885242.1 replication-associated recombination protein A -
E0F34_RS08145 1496338..1497657 - 1320 WP_061649864.1 glycoside hydrolase family 32 protein -
E0F34_RS08150 1497667..1498512 - 846 WP_000819519.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6368.47 Da        Isoelectric Point: 10.8214

>T288424 WP_000192221.1 NZ_LR536843:c1493625-1493452 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 174 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT288424 WP_000961810.1 NZ_LR536843:c1493415-1492963 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References