Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 28092..28789 Replicon genome plasmid 3
Accession NZ_LR536452
Organism Methylocella tundrae isolate MTUNDRAET4 annotated

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTUNDRAET4_RS19415 Protein ID WP_134493258.1
Coordinates 28367..28789 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTUNDRAET4_RS19410 Protein ID WP_134493256.1
Coordinates 28092..28370 (+) Length 93 a.a.

Genomic Context

MTUNDRAET4_RS19410MTUNDRAET4_RS19415MTUNDRAET4_RS19430MTUNDRAET4_RS19435MTUNDRAET4_RS19395MTUNDRAET4_RS19400MTUNDRAET4_RS19405MTUNDRAET4_RS19420MTUNDRAET4_RS19425
Location: 28092..28370 (279 bp)
Type: Antitoxin
Protein ID: WP_134493256.1
Location: 28367..28789 (423 bp)
Type: Toxin
Protein ID: WP_134493258.1
Location: 30006..31088 (1083 bp)
Type: Others
Protein ID: WP_134493264.1
Location: 32411..33628 (1218 bp)
Type: Others
Protein ID: WP_134493266.1
Location: 25423..25782 (360 bp)
Type: Others
Protein ID: WP_134493252.1
Location: 25779..26807 (1029 bp)
Type: Others
Protein ID: WP_134493505.1
Location: 26915..27490 (576 bp)
Type: Others
Protein ID: WP_134493254.1
Location: 28894..29478 (585 bp)
Type: Others
Protein ID: WP_134493260.1
Location: 29468..29764 (297 bp)
Type: Others
Protein ID: WP_134493262.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MTUNDRAET4_RS1939525423..25782-360WP_134493252.1hypothetical protein-
MTUNDRAET4_RS1940025779..26807-1029WP_134493505.1DUF1612 domain-containing protein-
MTUNDRAET4_RS1940526915..27490-576WP_134493254.1Uma2 family endonuclease-
MTUNDRAET4_RS1941028092..28370+279WP_134493256.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
MTUNDRAET4_RS1941528367..28789+423WP_134493258.1type II toxin-antitoxin system VapC family toxinToxin
MTUNDRAET4_RS1942028894..29478-585WP_134493260.1hypothetical protein-
MTUNDRAET4_RS1942529468..29764-297WP_134493262.1hypothetical protein-
MTUNDRAET4_RS1943030006..31088+1083WP_134493264.1site-specific integrase-
MTUNDRAET4_RS1943532411..33628+1218WP_134493266.1plasmid partitioning protein RepA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..208728208728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(15-75)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15326.51 Da        Isoelectric Point: 4.7306

>T288421 WP_134493258.1 NZ_LR536452:28367-28789 [Methylocella tundrae]
MNFLLDTNVLSEAQRPTPSARALAWLDAIDEDRVFLSVASIAELRRGVALLDEGRRRSALAAWLANDLPARFGGRILPID
QAVAERWGDLMAESRKTGTALSAMDGFFAATALARELTLVTRNVKDFAPFGVALLNPWED

Download         Length: 423 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9729.23 Da        Isoelectric Point: 10.7588

>AT288421 WP_134493256.1 NZ_LR536452:28092-28370 [Methylocella tundrae]
MPAPDKTAAPAAGAWTLASAKARLSEVVERAQASPQLITRNGKPAAVIVSAEEWAKKTLRKGTLAEFLLASPLRGAGLDL
ERQRDAPRDIAL

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References