Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 28092..28789 Replicon genome plasmid 3
Accession NZ_LR536452
Organism Methylocella tundrae isolate MTUNDRAET4 annotated

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTUNDRAET4_RS19415 Protein ID WP_134493258.1
Coordinates 28367..28789 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTUNDRAET4_RS19410 Protein ID WP_134493256.1
Coordinates 28092..28370 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTUNDRAET4_RS19395 25423..25782 - 360 WP_134493252.1 hypothetical protein -
MTUNDRAET4_RS19400 25779..26807 - 1029 WP_134493505.1 DUF1612 domain-containing protein -
MTUNDRAET4_RS19405 26915..27490 - 576 WP_134493254.1 Uma2 family endonuclease -
MTUNDRAET4_RS19410 28092..28370 + 279 WP_134493256.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTUNDRAET4_RS19415 28367..28789 + 423 WP_134493258.1 type II toxin-antitoxin system VapC family toxin Toxin
MTUNDRAET4_RS19420 28894..29478 - 585 WP_134493260.1 hypothetical protein -
MTUNDRAET4_RS19425 29468..29764 - 297 WP_134493262.1 hypothetical protein -
MTUNDRAET4_RS19430 30006..31088 + 1083 WP_134493264.1 site-specific integrase -
MTUNDRAET4_RS19435 32411..33628 + 1218 WP_134493266.1 plasmid partitioning protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..208728 208728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(15-75)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15326.51 Da        Isoelectric Point: 4.7306

>T288421 WP_134493258.1 NZ_LR536452:28367-28789 [Methylocella tundrae]
MNFLLDTNVLSEAQRPTPSARALAWLDAIDEDRVFLSVASIAELRRGVALLDEGRRRSALAAWLANDLPARFGGRILPID
QAVAERWGDLMAESRKTGTALSAMDGFFAATALARELTLVTRNVKDFAPFGVALLNPWED

Download         Length: 423 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9729.23 Da        Isoelectric Point: 10.7588

>AT288421 WP_134493256.1 NZ_LR536452:28092-28370 [Methylocella tundrae]
MPAPDKTAAPAAGAWTLASAKARLSEVVERAQASPQLITRNGKPAAVIVSAEEWAKKTLRKGTLAEFLLASPLRGAGLDL
ERQRDAPRDIAL

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References