Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2017516..2018030 Replicon chromosome
Accession NZ_LR536450
Organism Methylocella tundrae isolate MTUNDRAET4 annotated

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MTUNDRAET4_RS09345 Protein ID WP_134489356.1
Coordinates 2017704..2018030 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MTUNDRAET4_RS09340 Protein ID WP_197731972.1
Coordinates 2017516..2017704 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTUNDRAET4_RS09305 2012989..2013405 - 417 WP_134489340.1 DUF1236 domain-containing protein -
MTUNDRAET4_RS09315 2013723..2014736 - 1014 WP_134489345.1 extensin family protein -
MTUNDRAET4_RS09320 2014831..2015253 + 423 WP_134489347.1 aminoacyl-tRNA hydrolase -
MTUNDRAET4_RS09325 2015299..2015795 - 497 Protein_1840 DUF2852 domain-containing protein -
MTUNDRAET4_RS09330 2015929..2016720 - 792 WP_134489349.1 inositol monophosphatase -
MTUNDRAET4_RS09335 2016717..2017289 - 573 WP_134489351.1 elongation factor P -
MTUNDRAET4_RS09340 2017516..2017704 + 189 WP_197731972.1 antitoxin MazE family protein Antitoxin
MTUNDRAET4_RS09345 2017704..2018030 + 327 WP_134489356.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MTUNDRAET4_RS09350 2018226..2019530 + 1305 WP_134489358.1 hypothetical protein -
MTUNDRAET4_RS09355 2019625..2019741 - 117 Protein_1846 DNA polymerase III subunit beta -
MTUNDRAET4_RS09360 2020072..2020359 + 288 WP_134489360.1 co-chaperone GroES -
MTUNDRAET4_RS09365 2020408..2022051 + 1644 WP_134489362.1 chaperonin GroEL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(2-59)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11657.69 Da        Isoelectric Point: 6.2655

>T288420 WP_134489356.1 NZ_LR536450:2017704-2018030 [Methylocella tundrae]
MKRGQFVVVATSGDYGKPRPALVMQSDLFAELPSAIICPLTTTLRDDADLFRLEVSPSPRNGLREISQIAIDKLTVVPIA
KIGDVIGQADDALLLRVNRALALFLGIV

Download         Length: 327 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6951.90 Da        Isoelectric Point: 7.9809

>AT288420 WP_197731972.1 NZ_LR536450:2017516-2017704 [Methylocella tundrae]
MASYRQRMRAAGLRPVQIWAPDSRAPDFAEKCRAQARAVAASDPAGDEIMRFVASVYEWPEP

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References