Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2017516..2018030 Replicon chromosome
Accession NZ_LR536450
Organism Methylocella tundrae isolate MTUNDRAET4 annotated

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MTUNDRAET4_RS09345 Protein ID WP_134489356.1
Coordinates 2017704..2018030 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MTUNDRAET4_RS09340 Protein ID WP_197731972.1
Coordinates 2017516..2017704 (+) Length 63 a.a.

Genomic Context

MTUNDRAET4_RS09320MTUNDRAET4_RS09340MTUNDRAET4_RS09345MTUNDRAET4_RS09350MTUNDRAET4_RS09360MTUNDRAET4_RS09365MTUNDRAET4_RS09305MTUNDRAET4_RS09315MTUNDRAET4_RS09325MTUNDRAET4_RS09330MTUNDRAET4_RS09335MTUNDRAET4_RS09355
Location: 2014831..2015253 (423 bp)
Type: Others
Protein ID: WP_134489347.1
Location: 2017516..2017704 (189 bp)
Type: Antitoxin
Protein ID: WP_197731972.1
Location: 2017704..2018030 (327 bp)
Type: Toxin
Protein ID: WP_134489356.1
Location: 2018226..2019530 (1305 bp)
Type: Others
Protein ID: WP_134489358.1
Location: 2020072..2020359 (288 bp)
Type: Others
Protein ID: WP_134489360.1
Location: 2020408..2022051 (1644 bp)
Type: Others
Protein ID: WP_134489362.1
Location: 2012989..2013405 (417 bp)
Type: Others
Protein ID: WP_134489340.1
Location: 2013723..2014736 (1014 bp)
Type: Others
Protein ID: WP_134489345.1
Location: 2015299..2015795 (497 bp)
Type: Others
Protein ID: Protein_1840
Location: 2015929..2016720 (792 bp)
Type: Others
Protein ID: WP_134489349.1
Location: 2016717..2017289 (573 bp)
Type: Others
Protein ID: WP_134489351.1
Location: 2019625..2019741 (117 bp)
Type: Others
Protein ID: Protein_1846
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MTUNDRAET4_RS093052012989..2013405-417WP_134489340.1DUF1236 domain-containing protein-
MTUNDRAET4_RS093152013723..2014736-1014WP_134489345.1extensin family protein-
MTUNDRAET4_RS093202014831..2015253+423WP_134489347.1aminoacyl-tRNA hydrolase-
MTUNDRAET4_RS093252015299..2015795-497Protein_1840DUF2852 domain-containing protein-
MTUNDRAET4_RS093302015929..2016720-792WP_134489349.1inositol monophosphatase-
MTUNDRAET4_RS093352016717..2017289-573WP_134489351.1elongation factor P-
MTUNDRAET4_RS093402017516..2017704+189WP_197731972.1antitoxin MazE family proteinAntitoxin
MTUNDRAET4_RS093452017704..2018030+327WP_134489356.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MTUNDRAET4_RS093502018226..2019530+1305WP_134489358.1hypothetical protein-
MTUNDRAET4_RS093552019625..2019741-117Protein_1846DNA polymerase III subunit beta-
MTUNDRAET4_RS093602020072..2020359+288WP_134489360.1co-chaperone GroES-
MTUNDRAET4_RS093652020408..2022051+1644WP_134489362.1chaperonin GroEL-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(2-59)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11657.69 Da        Isoelectric Point: 6.2655

>T288420 WP_134489356.1 NZ_LR536450:2017704-2018030 [Methylocella tundrae]
MKRGQFVVVATSGDYGKPRPALVMQSDLFAELPSAIICPLTTTLRDDADLFRLEVSPSPRNGLREISQIAIDKLTVVPIA
KIGDVIGQADDALLLRVNRALALFLGIV

Download         Length: 327 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6951.90 Da        Isoelectric Point: 7.9809

>AT288420 WP_197731972.1 NZ_LR536450:2017516-2017704 [Methylocella tundrae]
MASYRQRMRAAGLRPVQIWAPDSRAPDFAEKCRAQARAVAASDPAGDEIMRFVASVYEWPEP

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References