Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3850783..3851401 Replicon chromosome
Accession NZ_LR536431
Organism Escherichia coli isolate f9610206-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag E4Z82_RS19335 Protein ID WP_001291435.1
Coordinates 3851183..3851401 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag E4Z82_RS19330 Protein ID WP_000344800.1
Coordinates 3850783..3851157 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z82_RS19320 3845872..3847065 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
E4Z82_RS19325 3847088..3850237 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
E4Z82_RS19330 3850783..3851157 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
E4Z82_RS19335 3851183..3851401 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
E4Z82_RS19340 3851573..3852124 + 552 WP_000102569.1 maltose O-acetyltransferase -
E4Z82_RS19345 3852240..3852710 + 471 WP_000136192.1 YlaC family protein -
E4Z82_RS19350 3852991..3853959 - 969 WP_000654812.1 IS5-like element IS903B family transposase -
E4Z82_RS19355 3853979..3855490 + 1512 WP_050487596.1 cyclic-guanylate-specific phosphodiesterase PdeB -
E4Z82_RS19360 3855532..3855885 - 354 WP_000878140.1 DUF1428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3852991..3853914 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T288416 WP_001291435.1 NZ_LR536431:3851183-3851401 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT288416 WP_000344800.1 NZ_LR536431:3850783-3851157 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References