Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-RHH |
Location | 2621161..2621680 | Replicon | chromosome |
Accession | NZ_LR536431 | ||
Organism | Escherichia coli isolate f9610206-5e81-11e8-bf7f-3c4a9275d6c8 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A837F4A9 |
Locus tag | E4Z82_RS13090 | Protein ID | WP_000277490.1 |
Coordinates | 2621396..2621680 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A6P1V8C3 |
Locus tag | E4Z82_RS13085 | Protein ID | WP_000124732.1 |
Coordinates | 2621161..2621403 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E4Z82_RS13060 | 2616886..2616996 | + | 111 | Protein_2512 | recombinase family protein | - |
E4Z82_RS13070 | 2617058..2617762 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
E4Z82_RS13075 | 2617824..2619758 | + | 1935 | Protein_2514 | Tn3 family transposase | - |
E4Z82_RS13080 | 2619794..2620588 | + | 795 | Protein_2515 | replication initiator protein RepA | - |
E4Z82_RS13085 | 2621161..2621403 | + | 243 | WP_000124732.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
E4Z82_RS13090 | 2621396..2621680 | + | 285 | WP_000277490.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
E4Z82_RS13095 | 2621818..2621910 | - | 93 | Protein_2518 | DNA partition complex ParG | - |
E4Z82_RS25585 | 2622416..2622748 | - | 333 | Protein_2519 | glycogen/starch synthase | - |
E4Z82_RS13105 | 2622748..2623269 | - | 522 | Protein_2520 | glucose-1-phosphate adenylyltransferase | - |
E4Z82_RS13110 | 2623332..2624036 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
E4Z82_RS13115 | 2624084..2624275 | + | 192 | WP_001446477.1 | helix-turn-helix domain-containing protein | - |
E4Z82_RS13120 | 2624373..2624789 | - | 417 | WP_088765932.1 | type II toxin-antitoxin system VapC family toxin | - |
E4Z82_RS13125 | 2624786..2625016 | - | 231 | WP_001261282.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
E4Z82_RS13130 | 2624973..2625434 | + | 462 | WP_162535865.1 | hypothetical protein | - |
E4Z82_RS13135 | 2625578..2625928 | + | 351 | WP_000493399.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2607706..2644380 | 36674 | |
- | inside | IScluster/Tn | - | - | 2617058..2655790 | 38732 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837F4A9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6P1V8C3 |