Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 928167..928821 Replicon chromosome
Accession NZ_LR536431
Organism Escherichia coli isolate f9610206-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag E4Z82_RS04610 Protein ID WP_000244777.1
Coordinates 928414..928821 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag E4Z82_RS04605 Protein ID WP_000354046.1
Coordinates 928167..928433 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z82_RS04580 923336..924079 + 744 WP_000951964.1 SDR family oxidoreductase -
E4Z82_RS04585 924136..925569 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
E4Z82_RS04590 925614..925925 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
E4Z82_RS04595 926089..926748 + 660 WP_000250274.1 hemolysin III family protein -
E4Z82_RS04600 926944..927924 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
E4Z82_RS04605 928167..928433 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
E4Z82_RS04610 928414..928821 + 408 WP_000244777.1 toxin CptA Toxin
E4Z82_RS04615 928861..929382 - 522 WP_001055874.1 flavodoxin FldB -
E4Z82_RS04620 929494..930390 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
E4Z82_RS04625 930415..931125 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E4Z82_RS04630 931131..932864 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T288406 WP_000244777.1 NZ_LR536431:928414-928821 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT288406 WP_000354046.1 NZ_LR536431:928167-928433 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References