Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 339541..340172 Replicon chromosome
Accession NZ_LR536431
Organism Escherichia coli isolate f9610206-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name hicA Uniprot ID A0A377MSE5
Locus tag E4Z82_RS01615 Protein ID WP_001259383.1
Coordinates 339541..339816 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag E4Z82_RS01620 Protein ID WP_000593555.1
Coordinates 339813..340172 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z82_RS01605 335603..338338 + 2736 WP_000149173.1 ribosome-associated ATPase/putative transporter RbbA -
E4Z82_RS01610 338338..339468 + 1131 WP_023063085.1 ABC transporter permease -
E4Z82_RS01615 339541..339816 + 276 WP_001259383.1 type II toxin-antitoxin system HicA family toxin Toxin
E4Z82_RS01620 339813..340172 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4Z82_RS01625 340292..340693 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
E4Z82_RS01630 340699..341505 - 807 WP_000173704.1 nickel import ATP-binding protein NikE -
E4Z82_RS01635 341502..342266 - 765 WP_001136207.1 nickel import ATP-binding protein NikD -
E4Z82_RS01640 342266..343099 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
E4Z82_RS01645 343096..344040 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 318975..340693 21718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10209.98 Da        Isoelectric Point: 10.7076

>T288403 WP_001259383.1 NZ_LR536431:339541-339816 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGPRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT288403 WP_000593555.1 NZ_LR536431:339813-340172 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377MSE5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References